Three categories of ZAP conjugates
Three categories of ZAP conjugates Read More »
CB1 receptors on a subset of vagal afferent neurons modulate voluntary ethanol intake in mice
Herrerias A, Oliverio A, Dvorácskó S, Thyagarajan A, Chedester L, Liu J, Cinar R, Iyer MR, Kunos G, Godlewski G (2025) CB1 receptors on a subset of vagal afferent neurons modulate voluntary ethanol intake in mice. Mol Psychiatry doi: 10.1038/s41380-025-03266-9 PMID: 40975751 Related Products: Anti-CB1-SAP (Cat. #IT-104), Blank-SAP (Cat. #IT-21)
Melanopsin Antibody Recent Publications
We’re highlighting one of our antibodies, a rabbit polyclonal against Melanopsin. This antibody is offered as both serum (AB-N38) and affinity purified (AB-N39). Intrinsically photosensitive retinal ganglion cells (ipRGCs) are cells that express melanopsin. These ipRGCs, with their long processes, are involved in the perception of light and dark and are circadian rhythm determinants. Our
Melanopsin Antibody Recent Publications Read More »
How many antibody molecules can ZAP bind to? What’s the recommended concentration?
Question I am using your Fab-ZAP Human (IT-51) and I want to know how many antibody molecules can a secondary antibody conjugate theoretically bind to? Answer A whole IgG (bivalent) secondary antibody in theory is capable of binding two antigen molecules. Since our Fab-ZAP conjugates actually use a monovalent secondary antibody, in theory they would
How many antibody molecules can ZAP bind to? What’s the recommended concentration? Read More »
Antagonists vs. Targeted Toxins
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Antagonists vs. Targeted Toxins Read More »
Meningeal macrophages mask incision pain sensitization in male rats
Kolahdouzan M, Ghazisaeidi S, Tu Y, Muley M, Gambeta E, Salter M (2025) Meningeal macrophages mask incision pain sensitization in male rats. Mol Pain doi: 10.1177/17448069251383593 Objective: To investigate whether CD206+macrophages in the meninges play a role in regulating nociception and pain hypersensitivity. Summary: The results indicate that while CD206+ meningeal macrophages do not regulate
Meningeal macrophages mask incision pain sensitization in male rats Read More »
The physiological and pathological mechanisms of LIN2, LIN7, LIN10 and their tripartite complex
Shang Y, Gan X, Dang Y, Liu J, Liu P (2025) The physiological and pathological mechanisms of LIN2, LIN7, LIN10 and their tripartite complex. J Cell Mol Med 29(15):e70794. doi: 10.1111/jcmm.70794 PMID: 40801824 Objective: To furnish a robust theoretical foundation for the prospective utilization of polarity proteins and their complex as cancer markers and therapeutic
Alteration of BDNF and noradrenergic markers in locus coeruleus in a mouse model of cancer-induced bone pain
Yuan M, Zhang L, Zhu H, Xie M (2025) Alteration of BDNF and noradrenergic markers in locus coeruleus in a mouse model of cancer-induced bone pain. PLoS One 20(8):e0330207. doi: 10.1371/journal.pone.0330207 PMID: 40811566 Objective: To examine the expression and localization of BDNF and NE neuron-specific proteins in the locus coeruleus (LC) of mice with cancer-induced