Choi PP, Wang Q, Brenner LA, Li AJ, Ritter RC, Appleyard SM (2024) Lesion of NPY receptor-expressing neurons in perifornical lateral hypothalamus attenuates glucoprivic feeding. Endocrinology 165(5):bqae021. doi: 10.1210/endocr/bqae021 PMID: 38368624
Objective: To elucidate the impact of lesioning NPY receptor-expressing neurons in the perifornical lateral hypothalamus (PeFLH) on glucoprivic feeding in rats.
Summary: Lesioning NPY receptor-expressing neurons in the perifornical lateral hypothalamus using NPY-SAP significantly attenuated glucoprivic feeding induced by 2DG, without affecting other counterregulatory responses like increased locomotor activity or corticosterone release. This study underscores the specific role of these neurons in glucose deficit-induced feeding responses in both male and female rats, highlighting a targeted approach for potentially modulating this critical energy balance mechanism.
Usage: NPY-SAP (IT-28) or Blank-SAP (IT-21) (50 ng per 100nL/site) dissolved in 0.01 M phosphate buffer (pH 7.4) was infused slowly over a 5 minute period directed to the PeFLH (stereotaxic coordinates: 2.8 mm caudal from bregma, +/−1.2 mm lateral to the midline, and −7.4 mm from the dura mater).
Related Products: NPY-SAP (Cat. #IT-28), Blank-SAP (Cat. #IT-21)