NPY-SAP [IT-28, KIT-28]

a tool for eliminating cells that express the Neuropeptide Y Receptor (NPYR); targeted via NPY, eliminated via saporin

SKU: IT-28 Categories: , Reactivity: Mouse, rat | Conjugate: saporin | Usage: eliminates cells |

Neuropeptide Y (NPY) receptor is the most abundant neuropeptide in the brain and is involved in many processes from prenatal to mature animals. It promotes the proliferation of postnatal neuronal precursor cells and exhibits a diverse range of important physiologic activities, including effects on psychomotor activity, food intake, regulation of central endocrine secretion, and potent vasoactive effects on the cardiovascular system. Neuropeptide Y family of peptides signal through a family of G protein-coupled receptors present in the brain and sympathetic neurons. These NPY receptors recognize NPY and related peptides.

NPY-SAP is a chemical conjugate of neuropeptide Y and the ribosome-inactivating protein, saporin. It specifically eliminates cells expressing the NPY receptor in rat and mouse.

NPY-SAP is available individually (Cat. #IT-28) or as a kit (Cat. #KIT-28) which includes NPY-SAP and Blank-SAP (Cat. #IT-21).

Targeting Collection (Cat. #TC-01) is sample pack of targeted toxins is useful in studying various aspects of satiety, appetite, and metabolism. It contains samples of NPY-SAP (Cat. #IT-28)Oxytocin-SAP (Cat. #IT- 46)Leptin-SAP (Cat. #IT-47), and Saporin (Cat. #PR-01).