Oxytocin is a nine amino acid peptide with a structure similar to vasopressin, and is a hormone released by the posterior pituitary. Peripheral activity of oxytocin is linked primarily to lactation and labor-related uterine contractions. Within the brain, oxytocin receptor-positive neurons have been studied with regard to their sensitivity to leptin and involvement in satiety.
Oxytocin-SAP is a chemical conjugate of native oxytocin peptide and the ribosome-inactivating protein, saporin. It specifically eliminates cells that recognize and internalize oxytocin in rat and mouse.
keywords: oxytocin, saporin, Somatostatin-positive interneurons, pyramidal neurons, hippocampus, neocortex, mossy cells, dentate gyrus