Oxytocin is a nine amino acid peptide with a structure similar to vasopressin, and is a hormone released by the posterior pituitary. Peripheral activity of oxytocin is linked primarily to lactation and labor-related uterine contractions. Within the brain, oxytocin receptor-positive neurons have been studied with regard to their sensitivity to leptin and involvement in satiety. Oxytocin-SAP recognizes and specifically eliminates cells expressing the oxytocin receptor.
There is evidence that NPY (NPY-SAP, Cat. #IT-28) can have an effect on oxytocin release, particularly in reproductive-related organs and processes (corpus luteum, lactation, etc.). Leptin (Leptin-SAP, Cat. #IT-47) is a key component in many obesity studies.
Oxytocin-SAP specifically eliminates cells that recognize and internalize oxytocin in rat and mouse. This targeted toxin is a chemical conjugate of native oxytocin peptide and the ribosome-inactivating protein, saporin.
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