Author name: Kristen Hartman

Increased systemic levels of centrally acting b-type natriuretic peptide are associated with chronic itch of different types

Nattkemper LA, Kim BS, Yap QV, Hoon MA, Mishra SK, Yosipovitch G (2024) Increased systemic levels of centrally acting b-type natriuretic peptide are associated with chronic itch of different types. J Invest Dermatol S0022-202X(24)00197-0. doi: 10.1016/j.jid.2024.02.026 PMID: 38522572 Objective: Examines plasma BNP levels and N-terminal pro-BNP levels in patients with differing types of chronic itch […]

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Cortical lipids containing choline mediate cannabinoid-induced cognitive improvement

Moreno-Rodríguez M, Martínez-Gardeazabal J, Bengoetxea de Tena I, Llorente-Ovejero A, Lombardero L, González de San Román E, Giménez-Llort L, Manuel I, Rodríguez-Puertas R (2024) Cortical lipids containing choline mediate cannabinoid-induced cognitive improvement. bioRxiv 2024.03.07.583670. doi: 10.1101/2024.03.07.583670 Objective: Investigate the neuroprotective effect of treatment with the CB1 cannabinoid agonist, WIN55,212-2, against cholinergic degeneration. Summary: The endocannabinoid

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Intercellular communication atlas reveals Oprm1 as a neuroprotective factor for retinal ganglion cells

Qian C, Xin Y, Qi C, Wang H, Dong BC, Zack DJ, Blackshaw S, Hattar S, Zhou FQ, Qian J (2024) Intercellular communication atlas reveals Oprm1 as a neuroprotective factor for retinal ganglion cells. Nat Commun 15(1):2206. doi: 10.1038/s41467-024-46428-z PMID: 38467611 Objective: To explore how intercellular communication contributes to retinal ganglion cell (RGC) survival following

Intercellular communication atlas reveals Oprm1 as a neuroprotective factor for retinal ganglion cells Read More »

Selective medial septum lesions in healthy rats induce longitudinal changes in microstructure of limbic regions, behavioral alterations, and increased susceptibility to status epilepticus

Luna-Munguia H, Gasca-Martinez D, Garay-Cortes A, Coutiño D, Regalado M, de Los Rios E, Villaseñor P, Hidalgo-Flores F, Flores-Guapo K, Benito BY, Concha L (2024) Selective medial septum lesions in healthy rats induce longitudinal changes in microstructure of limbic regions, behavioral alterations, and increased susceptibility to status epilepticus. Mol Neurobiol 61(10):1-21. doi: 10.1007/s12035-024-04069-9 PMID: 38443731

Selective medial septum lesions in healthy rats induce longitudinal changes in microstructure of limbic regions, behavioral alterations, and increased susceptibility to status epilepticus Read More »

Therapeutic peptides and proteins: Stabilization challenges and biomedical applications by means of nanodelivery systems

Berselli E, Coccolini C, Tosi G, Gokce EH, Oliveira MBPP, Fathi F, Krambeck K, Suoto EB (2024) Therapeutic peptides and proteins: Stabilization challenges and biomedical applications by means of nanodelivery systems. Int J Pept Res Ther 30:15. doi: 10.1007/s10989-024-10592-z Objective: To discuss the stability problems of proteins and peptides that have driven the scientific community

Therapeutic peptides and proteins: Stabilization challenges and biomedical applications by means of nanodelivery systems Read More »

NGFR regulates stromal cell activation in germinal centers

Hernández-Barranco A, Santos V, Mazariegos MS, Caleiras E, Nogués L, Mourcin F, Léonard S, Oblet C, Genebrier S, Rossille D, Benguría A, Sanz A, Vázquez E, Dopazo A, Efeyan A, Ortega-Molina A, Cogne M, Tarte K, Peinado H (2024) NGFR regulates stromal cell activation in germinal centers. Cell Rep 43(2):113705. doi: 10.1016/j.celrep.2024.113705 PMID: 38307025 Objective:

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Engineering small protein based inhibitors and biodegraders for cytosolic delivery and targeting of the undruggable proteome

Chan A (2024) Engineering small protein based inhibitors and biodegraders for cytosolic delivery and targeting of the undruggable proteome. Univ Pennsylvania Thesis. Objective: Studying the delivery of saporin across the cell membrane encapsulated in lipid nanoparticles. Summary: Protein payloads, like saporin and others, are given negatively charged regions which create binding sites for cationic lipids

Engineering small protein based inhibitors and biodegraders for cytosolic delivery and targeting of the undruggable proteome Read More »

Women’s special issue series: Biomedicines

Polito L (2024) Women’s special issue series: Biomedicines. Biomedicines 12(3):471. doi: 10.3390/biomedicines12030471 PMID: 38540085 Summary: Saporin is a single-chain ribosome-inactivating protein (RIP) with low toxicity in cells and animals. When the protein is linked to a carrier that facilitates cellular uptake, the protein can become highly and selectively toxic to the cellular target of the

Women’s special issue series: Biomedicines Read More »

Women’s special issue series: Biomedicines

Polito L (2024) Women’s special issue series: Biomedicines. Biomedicines 12(3):471. doi: 10.3390/biomedicines12030471 PMID: 38540085 Summary: Saporin is a single-chain ribosome-inactivating protein (RIP) with low toxicity in cells and animals. When the protein is linked to a carrier that facilitates cellular uptake, the protein can become highly and selectively toxic to the cellular target of the

Women’s special issue series: Biomedicines Read More »

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