Oti T, Satoh K, Uta D, Nagafuchi J, Tateishi S, Ueda R, Takanami K, Young LJ, Galione A, Morris JF, Sakamoto T, Sakamoto H (2021) Oxytocin influences male sexual activity via non-synaptic axonal release in the spinal cord. Curr Biol 31(1):103-114.e5. doi: 10.1016/j.cub.2020.09.089 Summary: Oxytocin directly activates SEG (Spinal Ejaculation Generator)/GRP (Gastrin-Releasing Peptide) neurons via […]
Wang CH, Pandey S, Sivalingam K, Shibu MA, Kuo WW, Yu-LanYeh, Viswanadha VP, Lin YC, Liao SC, Huang CY (2021) Leech extract: A candidate cardioprotective against hypertension-induced cardiac hypertrophy and fibrosis. J Ethnopharmacol 264:113346. doi: 10.1016/j.jep.2020.113346 PMID: 32896627 Objective: To delineate the molecular mechanisms of medicinal leech extract in the treatment of cardiac hypertrophy and
Nizari S, Wells JA, Carare RO, Romero IA, Hawkes CA (2021) Loss of cholinergic innervation differentially affects eNOS-mediated blood flow, drainage of Aβ and cerebral amyloid angiopathy in the cortex and hippocampus of adult mice. Acta Neuropathol Commun 9(1):12. doi: 10.1186/s40478-020-01108-z Summary: In this report, icv administration of mu p75-SAP resulted in significant death of
Lim I, Mitsui R, Kameda M, Sellers DJ, Chess‐Williams R, Hashitani H (2021) Comparative effects of angiotensin II on the contractility of muscularis mucosae and detrusor in the pig urinary bladder. Neurourol Urodyn 40:102-111. doi: 10.1002/nau.24548 PMID: 33074588 Objective: To explore contractile actions of angiotensin II (AT2) on the muscularis mucosae (MM) of the bladder.
Castiello MC, Bosticardo M, Sacchetti N, Calzoni E, Fontana E, Yamazaki Y, Draghici E, Corsino C, Bortolomai I, Sereni L, Yu HH, Uva P, Palchaudhuri R, Scadden DT, Villa A, Notarangelo LD (2021) Efficacy and safety of anti-CD45-saporin as conditioning agent for RAG deficiency. J Allergy Clin Immunol 147(1):309-320.e6. doi: 10.1016/j.jaci.2020.04.033 Objective: To improve multi-lineage
Efficacy and safety of anti-CD45-saporin as conditioning agent for RAG deficiency. Read More »
Dezawa S, Nagasaka K, Watanabe Y, Takashima I (2021) Lesions of the nucleus basalis magnocellularis (Meynert) induce enhanced somatosensory responses and tactile hypersensitivity in rats. Exp Neurol 335:113493. doi: 10.1016/j.expneurol.2020.113493 Summary: The authors used 192-IgG-SAP to produce a selective cholinergic lesion in the nucleus basalis of Meynert (NBM) of rats and investigated whether the NBM
Duarte L, Alexandre M, Chaves A, Santos D, deSouza A, Bernacci L (2021) Plant-virus infection inhibitors: The great potential of Caryophyllales species. Physiol Mol Plant Pathol 113:101597. doi: 10.1016/j.pmpp.2020.101597 Related Products: Saporin (Cat. #PR-01)
Plant-virus infection inhibitors: The great potential of Caryophyllales species Read More »
Chew C, Sengelaub DR (2021) Exercise is neuroprotective on the morphology of somatic motoneurons following the death of neighboring motoneurons via androgen action at the target muscle. Dev Neurobiol 81(1):22-35. doi: 10.1002/dneu.22794 Objective: To determine where the necessary site of androgen action is for exercise-driven neuroprotective effects on induced dendritic atrophy. Summary: Exercise following neural
Puente BR (2021) Chronic pain in dogs (Dolor crónico en el perro). Zaragoza Spain: Gruppo Asis Biomedia, S. L.. Summary: The author presents a thorough overview of aspects of canine chronic pain. He includes SP-SAP (Substance P-Saporin) as an experimental drug, “its use as an adjuvant analgesic in dogs with bone cancer has been studied,”
Chronic pain in dogs (Dolor crónico en el perro) Read More »
Nelson TS, Taylor BK (2021) Targeting spinal neuropeptide Y1 receptor-expressing interneurons to alleviate chronic pain and itch. Prog Neurobiol 196:101894. doi: 10.1016/j.pneurobio.2020.101894 Summary: Intrathecal administration of NPY-SAP reduced several operant and cognitive measures of Complete Freund’s adjuvant (CFA)-induced allodynia, including responsiveness to cold temperatures, feeding interference, and an escape task, but did not interfere with