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Efficacy and safety of anti-CD45-saporin as conditioning agent for RAG deficiency.

Castiello MC, Bosticardo M, Sacchetti N, Calzoni E, Fontana E, Yamazaki Y, Draghici E, Corsino C, Bortolomai I, Sereni L, Yu HH, Uva P, Palchaudhuri R, Scadden DT, Villa A, Notarangelo LD (2021) Efficacy and safety of anti-CD45-saporin as conditioning agent for RAG deficiency. J Allergy Clin Immunol 147(1):309-320.e6. doi: 10.1016/j.jaci.2020.04.033

Objective: To improve multi-lineage engraftment using non-genotoxic conditioning with Anti-CD45-Saporin.

Summary: Conditioning with Anti-CD45 antibody-drug conjugates may represent a novel and safe conditioning regimen for patients with RAG deficiency and other inborn errors of immunity.

Usage: Intravenous injection of Anti-CD45-SAP (3 mg/kg).

Related Products: Streptavidin-ZAP (Cat. #IT-27)

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