Wang CH, Pandey S, Sivalingam K, Shibu MA, Kuo WW, Yu-LanYeh, Viswanadha VP, Lin YC, Liao SC, Huang CY (2021) Leech extract: A candidate cardioprotective against hypertension-induced cardiac hypertrophy and fibrosis. J Ethnopharmacol 264:113346. doi: 10.1016/j.jep.2020.113346 PMID: 32896627
Objective: To delineate the molecular mechanisms of medicinal leech extract in the treatment of cardiac hypertrophy and fibrosis, using both in vitro and in vivo assessments.
Summary: Pre-treatment with leech extract significantly reduced angiotensin II (ANG II)-induced cardiac hypertrophy and fibrosis.
Usage: Western blot; PVDF membranes were incubated with Anti-AT-1R.
Related Products: Angiotensin II receptor (AT-1R) Rabbit Polyclonal, affinity-purified (Cat. #AB-N27AP)