Author name: Kristen Hartman

KDM6A promotes imatinib resistance through YY1-mediated transcriptional upregulation of TRKA independently of its demethylase activity in chronic myelogenous leukemia

Zhang C, Shen L, Zhu Y, Xu R, Deng Z, Liu X, Ding Y, Wang C, Shi Y, Bei L, Wei D, Thorne RF, Zhang XD, Yu L, Chen S (2021) KDM6A promotes imatinib resistance through YY1-mediated transcriptional upregulation of TRKA independently of its demethylase activity in chronic myelogenous leukemia. Theranostics 11(6):2691-2705. doi: 10.7150/thno.50571 PMID: […]

KDM6A promotes imatinib resistance through YY1-mediated transcriptional upregulation of TRKA independently of its demethylase activity in chronic myelogenous leukemia Read More »

Aberrant functional connectivity of basal forebrain subregions with cholinergic system in short-term and chronic insomnia disorder

Ma X, Fu S, Yin Y, Wu Y, Wang T, Xu G, Liu M, Xu Y, Tian J, Jiang G (2021) Aberrant functional connectivity of basal forebrain subregions with cholinergic system in short-term and chronic insomnia disorder. J Affect Disord 278:481-487. doi: 10.1016/j.jad.2020.09.103 Summary: Previous animal studies have identified the cholinergic basal forebrain (CBF) as

Aberrant functional connectivity of basal forebrain subregions with cholinergic system in short-term and chronic insomnia disorder Read More »

Intracellular delivery methods using biofunctional peptide-modified extracellular vesicles

Nakase I (2020) Intracellular delivery methods using biofunctional peptide-modified extracellular vesicles. Extracell Vesicles Circ Nucleic Acids 1:44. American Society for Exosomes and Microvesicles 2020 Annual Meeting. doi: 10.20517/evcna.2020.10 Related Products: Saporin (Cat. #PR-01)

Intracellular delivery methods using biofunctional peptide-modified extracellular vesicles Read More »

From obesity to hippocampal neurodegeneration: Pathogenesis and non-pharmacological interventions

Lee TH, Yau SY (2021) From obesity to hippocampal neurodegeneration: Pathogenesis and non-pharmacological interventions. Int J Mol Sci 22(1):201. doi: 10.3390/ijms22010201 Summary: This review provides insights into how chronic metabolic disorders, like obesity, could impair brain health and cognitive functions in later life. The authors reference the use of CCK-SAP into the nodose ganglia to

From obesity to hippocampal neurodegeneration: Pathogenesis and non-pharmacological interventions Read More »

Obesity shapes metabolism in the tumor microenvironment to suppress anti-tumor immunity

Ringel AE, Drijvers JM, Baker GJ, Catozzi A, García-Cañaveras JC, Gassaway BM, Miller BC, Juneja VR, Nguyen TH, Joshi S, Yao CH, Yoon H, Sage PT, LaFleur MW, Trombley JD, Jacobson CA, Maliga Z, Gygi SP, Sorger PK, Rabinowitz JD, Sharpe AH, Haigis MC (2020) Obesity shapes metabolism in the tumor microenvironment to suppress anti-tumor

Obesity shapes metabolism in the tumor microenvironment to suppress anti-tumor immunity Read More »

Potential roles of neuronal nitric oxide synthase and the PTEN-induced kinase 1 (PINK1)/Parkin pathway for mitochondrial protein degradation in disuse-induced soleus muscle atrophy in adult rats

Uda M, Yoshihara T, Ichinoseki-Sekine N, Baba T, Yoshioka T (2020) Potential roles of neuronal nitric oxide synthase and the PTEN-induced kinase 1 (PINK1)/Parkin pathway for mitochondrial protein degradation in disuse-induced soleus muscle atrophy in adult rats. PLoS One 15(12):e0243660. doi: 10.1371/journal.pone.0243660 PMID: 33296434 Objective: To investigate the involvement of neuronal nitric oxide synthase (nNOS)

Potential roles of neuronal nitric oxide synthase and the PTEN-induced kinase 1 (PINK1)/Parkin pathway for mitochondrial protein degradation in disuse-induced soleus muscle atrophy in adult rats Read More »

Short oligoalanine helical peptides for supramolecular nanopore assembly and protein cytosolic delivery

Pazo M, Salluce G, Lostalé-Seijo I, Juanes M, Gonzalez F, Garcia-Fandiño R, Montenegro J (2021) Short oligoalanine helical peptides for supramolecular nanopore assembly and protein cytosolic delivery. RSC Chem Biol 2:503-512. doi: 10.1039/D0CB00103A Related Products: Saporin (Cat. #PR-01)

Short oligoalanine helical peptides for supramolecular nanopore assembly and protein cytosolic delivery Read More »

Measuring attention in rats with a visual signal detection task: Signal intensity vs. signal duration

Holloway Z, Koburov R, Hawkey A, Levin ED (2020) Measuring attention in rats with a visual signal detection task: Signal intensity vs. signal duration. Pharmacol Biochem Behav 199:173069. doi: 10.1016/j.pbb.2020.173069 Summary: Drug-induced effects have been used to demonstrate the construct validity of operant attention tasks, as well as to assess the pharmacological systems that underlie

Measuring attention in rats with a visual signal detection task: Signal intensity vs. signal duration Read More »

Extracellular levels of the sleep homeostasis mediator, adenosine, are regulated by glutamatergic neurons during wakefulness and sleep

Sun MJ, Tang Y (2020) Extracellular levels of the sleep homeostasis mediator, adenosine, are regulated by glutamatergic neurons during wakefulness and sleep. Purinergic Signal 16(4):475-476. doi: 10.1007/s11302-020-09758-3 Summary: Blanco-Centurion et al. investigated the role of cholinergic neurons in the BF by administering 192–IgG–SAP to lesion them, but surprisingly the results indicated that adenosine from cholinergic

Extracellular levels of the sleep homeostasis mediator, adenosine, are regulated by glutamatergic neurons during wakefulness and sleep Read More »

Exercise is neuroprotective to motoneuron dendrites following partial motoneuron depletion via a mechanism dependent on androgen receptors at the target muscle

Chew C (2020) Exercise is neuroprotective to motoneuron dendrites following partial motoneuron depletion via a mechanism dependent on androgen receptors at the target muscle. Indiana Univ, Dept Psychol & Brain Sci Thesis. See: Chew C et al. Exercise promotes recovery after motoneuron injury via hormonal mechanisms. Neural Regen Res 15(8):1373-1376, 2020. Related Products: CTB-SAP (Cat.

Exercise is neuroprotective to motoneuron dendrites following partial motoneuron depletion via a mechanism dependent on androgen receptors at the target muscle Read More »

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