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  4. Lesions of the nucleus basalis magnocellularis (Meynert) induce enhanced somatosensory responses and tactile hypersensitivity in rats.

Lesions of the nucleus basalis magnocellularis (Meynert) induce enhanced somatosensory responses and tactile hypersensitivity in rats.

Dezawa S, Nagasaka K, Watanabe Y, Takashima I (2021) Lesions of the nucleus basalis magnocellularis (Meynert) induce enhanced somatosensory responses and tactile hypersensitivity in rats. Exp Neurol 335:113493. doi: 10.1016/j.expneurol.2020.113493

Summary: The authors used 192-IgG-SAP to produce a selective cholinergic lesion in the nucleus basalis of Meynert (NBM) of rats and investigated whether the NBM lesion led to tactile hypersensitivity in the forepaw. Results suggest that neuronal loss in the NBM diminishes acetylcholine actions in the S1, thereby enhancing the cortical representation of sensory stimuli, which may in turn lead to behavioral hypersensitivity.

Usage: The lesion group received injection of 0.3 μL of 192-IgG-SAP into the left nucleus basalis of Meynert (NBM).

Related Products: 192-IgG-SAP (Cat. #IT-01)