Keilholz A, Homan C, Schroeder A, Osman K, Smith C, Pathak I, Streeter K, Ozden I, Ma L, Lever T, Nichols N (2023) Tongue exercise-induced functional and structural upper airway plasticity in a rodent model of hypoglossal (XII) motor neuron loss. American Physiology Summit 2023 Meeting Abstracts 38(S1) Objective: Examine if upper airway function/coordination can […]
Holborough-Kerkvliet MD, Kroos S, van de Wetering R, Toes REM (2023) Addressing the key issue: Antigen-specific targeting of B cells in autoimmune diseases. Immunol Lett 259:37-45. doi: 10.1016/j.imlet.2023.05.005 PMID: 37209914 Objective: Using cyclic citrullinated peptide (CCP) conjugated to CNBz and saporin to eliminate autoreactive B cells, as a treatment for rheumatoid arthritis (RA). Summary: Joint
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Chen CH, Tsai TC, Wu YJ, Hsu KS (2023) Gastric vagal afferent signaling to the basolateral amygdala mediates anxiety-like behaviors in experimental colitis mice. JCI Insight e161874. doi: 10.1172/jci.insight.161874 PMID: 37200091 Objective: This study aimed to characterize gut-to-brain signaling and brain circuitry responsible for anxiety-like behaviors in a mouse model of inflammatory bowel disease. Summary:
Targeted Toxins for Neuroscience Antibody Screening for Neuroscience There is a growing need for therapeutics for cancer, autoimmune diseases, blood diseases and Alzheimer’s disease. Due to their ability to bind to a specific target antigen, monoclonal antibodies are increasingly being screened for therapeutic drug development. In May 2021, the FDA approved the 100th monoclonal antibody
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One of the more common methods of using Streptavidin-ZAP is to couple the complex with biotinylated antibodies. However, there are also many instances of biotinylated ligands, peptides, and even biotinylated major histocompatibility complex (MHC) tetramers in immunology fields. B-Cell Targeting. An example of utilizing Streptavidin-ZAP to study ligands that target CD22 were shown by Collins
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NGFr (ME20.4, p75) Mouse Monoclonal (Cat. #AB-N07) The p75 neurotrophin receptor (p75NTR), also known as the low affinity nerve growth factor receptor, binds nerve growth factor, brain-derived neurotrophic factor, neurotrophin-3 and neurotrophin-4 with varying specificities. The p75NTR plays an important role in neurotrophic factor signaling and has been shown to modulate the susceptibility of selective
Sainz AE (2023) The effects of loss of orexin neurons on attention. William & Mary Thesis. Objective: This paper examines the effects of loss of orexin neurons on attention in mice. Summary: This undergraduate honors thesis from William & Mary tested attention in mice after selective loss of orexin neurons, which are important for arousal.
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Choi P (2023) The VLM a1/c1 ca/npy neuronal projections to the perifornical area of the lateral hypothalamus and its functional role in glucoprivic feeding. Washington State Univ Thesis. Objective: This dissertation aimed to determine the role of neuropeptide Y (NPY) receptor signaling from the ventrolateral medulla (VLM) catecholamine (CA) neurons in the lateral hypothalamus (LHA)
May 12-14, Booth 5067 Molecular Surgery definition: Specifically remove cells based on a unique cell surface marker; useful in both in vitro (e.g., antibody screening) and in vivo (e.g., ‘knock out’ models, functionomics) applications. Visit Booth 5067, May 12-14 and find out how you can use Molecular Surgery. Curated Resources Saporin Uses in Immunology Immunology
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