Streptavidin-pHast: A readily conjugatable, pH-sensitive dye to screen for internalization Shramm PA, Ancheta L (2019) Proceedings of the American Association for Cancer Research Annual Meeting, Atlanta GA. Abstract The quick and efficient screening of targeting agents that internalize effectively is vital for determining suitability as potential therapeutics. Some of the most recent successes in the […]
Antonia-Nancy H, Matsumoto M, Tahara Y (2023) Self-assembled nanogels consisting of cholesterol-bearing polysaccharides and their applications in medicine. (eds. Dr. Chukwuebuka Emmanuel Umeyor, Dr. Emmanuel Uronnachi and Dr. Pratik Kakade). In: Hydrogels and Nanogels – Applications in Medicine doi: 10.5772/intechopen.1001981 Objective: Using iron oxide-containing nano-gels containing saporin to magnetically guide the targeting of saporin. Summary:
Zhou Q, Zheng Z, Wang X, Li W, Wang L, Yin C, Zhang Q, Wang Q (2023) taVNS alleviates sevoflurane-induced cognitive dysfunction in aged rats via activating basal forebrain cholinergic neurons. Neurochem Res 48(6):18481863. doi: 10.1007/s11064-023-03871-6 PMID: 36729311 Objective: To investigate if Sevoflurane, an inhalation anesthetic, inhibits cholinergic pathways that induce neuronal death and neuroinflammation,
Le Z, Pan Q, He A, Liu H, Shi Y, Liu L, Liu Z, Ping Y, Chen Y (2023) Direct cytosolic delivery of proteins and CRISPR-Cas9 genome editing by gemini amphiphiles via non-endocytic translocation pathways. ACS Cent Sci 9(7):1313-1326. doi: 10.1021/acscentsci.3c00207 PMID: 37521791 Objective: Create a library composed of 150 gemini amphiphiles (GAs), a molecule
Souza GMPR, Stornetta DS, Shi Y, Lim E, Berry FE, Bayliss DA, Abbott SBG (2023) Neuromedin B-expressing neurons in the retrotrapezoid nucleus regulate respiratory homeostasis and promote stable breathing in adult mice. J Neurosci JN-RM-0386-23. doi: 10.1523/JNEUROSCI.0386-23.2023 PMID: 37290937 Objective: To develop a transgenic mouse model and demonstrate that retrotrapezoid nucleus (RTN) neurons are fundamental
Harris RBS (2023) Low dose peripheral leptin infusion produces selective activation of ventromedial hypothalamic and hindbrain STAT3. Am J Physiol Endocrinol Metab 325(1):E72-E82. doi: 10.1152/ajpendo.00083.2023 PMID: 37285599 Objective: To show that the deletion of leptin-receptor expressing cells in the ventromedial hypothalamus (VMH) has no effect on basal body weight or body fat mass, but greatly
He X, Qu Y, Xiong S, Jiang Z, Tang Y, Yan F, Deng Y, Sun Y (2023) Functional l-arginine derivative as an efficient vector for intracellular protein delivery for potential cancer therapy. J Funct Biomater 14(6):301. doi: 10.3390/jfb14060301 PMID: 37367265 Objective: To address the instability of the 9-fluorenylmethyloxycarbonyl (Fmoc) group in aqueous medium. Summary: The
Porello I, Cellesi F (2023) Intracellular delivery of therapeutic proteins. New advancements and future directions. Front Bioeng Biotechnol 11:1211798. doi: 10.3389/fbioe.2023.1211798 PMID: 37304137 Objective: To provide a brief overview of the current methods for intracellular protein delivery to mammalian cells. Summary: The field of intracellular protein delivery is still a relatively young area of research
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