Zhou Q, Zheng Z, Wang X, Li W, Wang L, Yin C, Zhang Q, Wang Q (2023) taVNS alleviates sevoflurane-induced cognitive dysfunction in aged rats via activating basal forebrain cholinergic neurons. Neurochem Res 48(6):18481863. doi: 10.1007/s11064-023-03871-6 PMID: 36729311
Objective: To investigate if Sevoflurane, an inhalation anesthetic, inhibits cholinergic pathways that induce neuronal death and neuroinflammation, ultimately leading to Postoperative cognitive dysfunction.
Summary: Study indicated that taVNS might alleviate sevoflurane-induced hippocampal neuronal apoptosis, necroptosis and microglial activation though activating cholinergic system in the basal forebrain.
Usage: 192-IgG-SAP (IT-01) selectively lesioned cholinergic neurons in the basal forebrain.
Related Products: 192-IgG-SAP (Cat. #IT-01)