Ciriello J, Rosas-Arellano MP, Solano-Flores LP (2000) Intrathecal injections of saporin conjugated substance-P alter the development of renal hypertension. Neuroscience 2000 Abstracts 310.2. Society for Neuroscience, New Orleans, LA. Summary: We have recently shown that there is an up-regulation of mRNA encoding Substance-P (SP) in dorsal root ganglia in the two kidney, one clip (2K1C) […]
Vulchanova L, Olson TH, Elde R, Honda CN (2000) Role of IB4-binding sensory neurons in the effects of intradermal capsaicin injection. Neuroscience 2000 Abstracts 212.7. Society for Neuroscience, New Orleans, LA. Summary: We have shown previously that a unilateral injection of a conjugate of the lectin IB4 and the toxin saporin (IB4-SAP) into sciatic nerve
Role of IB4-binding sensory neurons in the effects of intradermal capsaicin injection. Read More »
Martin JL, Sloviter RS (2000) Focal hippocampal hyperexcitability after focal interneuron ablation in the rat by substance P-saporin. Neuroscience 2000 Abstracts 389.13. Society for Neuroscience, New Orleans, LA. Summary: Hyperexcitability after prolonged seizures or head trauma may result from interneuron malfunction or loss; but a causal relationship is in doubt because global insults produce widespread
Burgess SE, Vanderah TW, Mantyh PW, Malan Jr TP, Ossipov MH, Lappi D, Lai J, Porreca F (2000) Dermorphin-saporin targets tonic descending facilitation in the rostral ventromedial medulla to block and reverse neuropathic pain. Neuroscience 2000 Abstracts 243.6. Society for Neuroscience, New Orleans, LA. Summary: The hypothesis that chronic pain from L5/L6 spinal nerve ligation
Miller SA, Lappi DA, Wiley RG (2000) Intrathecal dermorphin-saporin decreases morphine effect in hotplate algesia testing. Neuroscience 2000 Abstracts 212.8. Society for Neuroscience, New Orleans, LA. Summary: The targeted cytotoxin, dermorphin-saporin, selectively destroys cells expressing MOR. In the present study, we gave dermorphin-saporin by lumbar i.t. injection and sought to determine if destroying dorsal horn
Intrathecal dermorphin-saporin decreases morphine effect in hotplate algesia testing. Read More »
Easton A, Ridley RM, Baker HF, Gaffan D (2000) Crossed unilateral lesions of the cholinergic basal forebrain (by me20.4IgG-saporin) and fornix from inferior temporal cortex produce severe learning impairments in rhesus monkeys. Neuroscience 2000 Abstracts 205.8. Society for Neuroscience, New Orleans, LA. Summary: Section of the anterior temporal stem, amygdala and fornix in monkeys results
McGaughy J, Everitt BJ, Robbins TW, Sarter M (2000) The role of cortical cholinergic afferent projections in cognition: impact of new selective immunotoxins. Behav Brain Res 115:251-263. doi: 10.1016/s0166-4328(00)00262-x Summary: Review and comparison of immunolesioning techniques. Related Products: 192-IgG-SAP (Cat. #IT-01), ME20.4-SAP (Cat. #IT-15)
Gunhan-Agar E, Choudary P, Landerholm TE, Chalupa LM (2000) Depletion of cholinergic amacrine cells does not perturb the segregation of on and off cone bipolar cell projections. Neuroscience 2000 Abstracts 119.3. Society for Neuroscience, New Orleans, LA. Summary: The pathways signaling onset and offset of light are segregated in the retina with On-cone and Off-cone
Rahimi O, Tatham D, Juliano SL (2000) Sensory training improves the ability to process stimuli in barrel cortex after basal forebrain lesion. Neuroscience 2000 Abstracts 51.22. Society for Neuroscience, New Orleans, LA. Summary: Lesions of the basal forebrain deplete the cerebral cortex of acetylcholine and result in decreased ability to process stimuli. Using a model
Bitner RS, Nikkel AL, Decker MW (2000) Immunohistochemical detection of alpha-7 nicotinic receptor expression by two distinct cell types in the dorsal raphe and locus coeruleus of rat. Neuroscience 2000 Abstracts 41.7. Society for Neuroscience, New Orleans, LA. Summary: The α7 nicotinic acetylcholine receptor (nAChR) subunit can be assembled to form a homomeric-pentamer with high