ATS has received a Small Business Innovation Research (SBIR) grant from the National Institute of Mental Health (NIMH) under the program announcement for competing continuation awards for pharmacologic agents and drugs for mental disorders. This three-year, $2.4 million award is a continuation of Phase II funding for the development of a drug for the treatment […]
ATS Receives $2.4 M Award for SP-SAP Drug Development Read More »
Contributed by Dr. Patrick O. Kanold, Dept Neurobiology, Harvard Medical School, Boston, MA 02115.Dr. Kanold summarizes his work with ME20.4-SAP. A complete report was published in Science 301:521-525. The processing of information in the visual system happens in multiple stages. Retinal neurons in the eye connect to neurons in the lateral geniculate nucleus (LGN), that
Cover Article: Subplate Neurons and Functional Maturation of Thalamocortical Synapses Read More »
I’Anson H, Sundling LA, Roland SM, Ritter S (2003) Immunotoxic destruction of distinct catecholaminergic neuron populations disrupts the reproductive response to glucoprivation in female rats. Endocrinology 144(10):4325-4331. doi: 10.1210/en.2003-0258 Summary: The authors hypothesized that hindbrain catcholamine neurons suppressed estrous cycles during chronic glucoprivation as an extension of their role in glucoprivic feeding. 42-ng bilateral injections
Moller LN, Stidsen CE, Hartmann B, Holst JJ (2003) Somatostatin receptors. Biochim Biophys Acta 1616(1):1-84. doi: 10.1016/s0005-2736(03)00235-9 PMID: 14507421 Related Products: Somatostatin Receptor-1 (SSTR1) Mouse Monoclonal (Cat. #AB-N35), Somatostatin Receptor-1 (SSTR1) Rabbit Polyclonal (Cat. #AB-N20), Somatostatin Receptor-5 (SSTR5) Mouse Monoclonal (Cat. #AB-N24)
Somatostatin receptors. Read More »
Tomaszewicz M, Rossner S, Schliebs R, Cwikowska J, Szutowicz A (2003) Changes in cortical acetyl-CoA metabolism after selective basal forebrain cholinergic degeneration by 192IgG-saporin. J Neurochem 87(2):318-324. doi: 10.1046/j.1471-4159.2003.01983.x Objective: To investigate whether cortical cholinergic input affects acetyl-CoA metabolism in cholinoceptive cortical target regions. Summary: Alzheimer’s disease subjects often show deficits in cerebral glucose metabolism.
Gadd CA, Murtra P, De Felipe C, Hunt SP (2003) Neurokinin-1 receptor-expressing neurons in the amygdala modulate morphine reward and anxiety behaviors in the mouse. J Neurosci 23(23):8271-8280. doi: 10.1523/JNEUROSCI.23-23-08271.2003 Summary: Mice lacking the neurokinin-1 (NK-1) receptor are insensitive to opiates in models of drug abuse. To assess what areas of the brain may be
Gardell LR, Vanderah TW, Gardell SE, Wang R, Ossipov MH, Lai J, Porreca F (2003) Enhanced evoked excitatory transmitter release in experimental neuropathy requires descending facilitation. J Neurosci 23(23):8370-8379. doi: 10.1523/JNEUROSCI.23-23-08370.2003 Summary: The authors examine whether afferent discharge produced by nerve injury and central changes in experimental neuropathic pain might interact at the spinal level.
Cadiacio CL, Milner TA, Gallagher M, Pierce JP (2003) Hilar neuropeptide Y interneuron loss in the aged rat hippocampal formation. Exp Neurol 183(1):147-158. doi: 10.1016/s0014-4886(03)00126-2 Summary: The authors investigate the loss of neuropeptide Y-immunoreactive (NPY-I) interneurons in the dentate gyrus of aged rats. Their results show a loss of a select group of interneurons in
Hilar neuropeptide Y interneuron loss in the aged rat hippocampal formation. Read More »
Scattoni ML, Calamandrei G, Ricceri L (2003) Neonatal cholinergic lesions and development of exploration upon administration of the GABAa receptor agonist muscimol in preweaning rats. Pharmacol Biochem Behav 76(2):213-221. doi: 10.1016/s0091-3057(03)00191-6 Summary: The authors investigated GABAergic development in young rats lesioned with two 0.42-ng injections of 192-Saporin (Cat. #IT-01) into the third ventricle. The rats
Birthelmer A, Lazaris A, Riegert C, Marques Pereira P, Koenig J, Jeltsch H, Jackisch R, Cassel JC (2003) Does the release of acetylcholine in septal slices originate from intrinsic cholinergic neurons bearing p75NTR receptors? A study using 192 IgG-saporin lesions in rats. Neuroscience 122(4):1059-1071. doi: 10.1016/j.neuroscience.2003.09.001 Summary: The authors used 0.8 µg injections of 192-Saporin