Author name: Kristen Hartman

192 IgG-saporin lesions to the nucleus basalis magnocellularis (nBM) disrupt acquisition of learning set formation.

Bailey AM, Rudisill ML, Hoof EJ, Loving ML (2003) 192 IgG-saporin lesions to the nucleus basalis magnocellularis (nBM) disrupt acquisition of learning set formation. Brain Res 969(1-2):147-159. doi: 10.1016/s0006-8993(03)02294-7 Summary: Previous studies by Bailey and others have used quisqualic acid to lesion the nucleus basalis (nBM) in order to understand Alzheimer’s disease. Injections of 75 […]

192 IgG-saporin lesions to the nucleus basalis magnocellularis (nBM) disrupt acquisition of learning set formation. Read More »

Ablation of striatal interneurons influences activities of entopeduncular neurons.

Chiken S, Tokuno H (2003) Ablation of striatal interneurons influences activities of entopeduncular neurons. Neuroreport 14(5):675-678. doi: 10.1097/00001756-200304150-00003 Summary: To investigate the role of the basal ganglia in informational processing of voluntary movement, the authors used SP-SAP (Cat. #IT-07) to lesion SP receptor-expressing neurons in the striatum. A 0.5 µl injection of 40 ng/µl SP-SAP

Ablation of striatal interneurons influences activities of entopeduncular neurons. Read More »

Retrograde Transport

Q: I’m interested in using SAP to eliminate cells through retrograde transport, like OX7-SAP (Cat. #IT-02) and IB4-SAP (Cat. #IT-10) have been used. Can you explain how retrograde transport works and if it is possible for this to work with dermorphin-SAP (Cat. #IT-12)? What determines whether a targeted toxin will be able to be used

Retrograde Transport Read More »

Effects of septal grafts on acetylcholine release from rat hippocampus after 192 IgG-saporin lesion.

Hilgert M, Hartmann J, Loffelholz K, Jeltsch H, Cassel JC, Klein J (2003) Effects of septal grafts on acetylcholine release from rat hippocampus after 192 IgG-saporin lesion. Neurochem Res 28(3-4):467-472. doi: 10.1023/a:1022852819018 Summary: A model for transplantation efficacy was created using injections of 400 ng each into the vertical limb of the rat diagonal band

Effects of septal grafts on acetylcholine release from rat hippocampus after 192 IgG-saporin lesion. Read More »

Long-term effects of decreased noradrenergic central nervous system innervation on pain behavior and opioid antinociception.

Jasmin L, Boudah A, Ohara PT (2003) Long-term effects of decreased noradrenergic central nervous system innervation on pain behavior and opioid antinociception. J Comp Neurol 460(1):38-55. doi: 10.1002/cne.10633 Summary: Noradrenaline (NA) is an essential element of the endogenous pain inhibitory system. The authors injected 5 µg of anti-DBH-SAP (Cat. #IT-03) into either the cerebral ventricles

Long-term effects of decreased noradrenergic central nervous system innervation on pain behavior and opioid antinociception. Read More »

Funding Awarded for SBIR Phase II Grant

SP SAP Drug Development /

On February 1, 2003 ATS was awarded an $800,000 grant from the National Institutes of Health, National Institute of Mental Health. This three-year grant will support the creation of monoclonal antibodies to the extracellular domains of G protein-coupled receptors. These receptors play an important role in all aspects of human health, reflecting their widespread presence

Funding Awarded for SBIR Phase II Grant Read More »

Cover Article: Biotinylated targeting. A viable option?

News Article /

For the IB4-SAP (Cat. #IT-10) illustration (Figure 1), our thanks to Christopher N. Honda, Ph.D., Associate Professor, Department of Neuroscience, University ofMinnesota, 6-145 Jackson Hall, 321 Church Street, Minneapolis, MN 55455 This issue of our quarterly newsletter addresses the use of biotinylated materials in targeting. ATS is now offering a biotinylation service (see p. 7)

Cover Article: Biotinylated targeting. A viable option? Read More »

Immunotoxin lesion of hypothalamically projecting norepinephrine and epinephrine neurons differentially affects circadian and stressor-stimulated corticosterone secretion.

Ritter S, Watts AG, Dinh TT, Sanchez-Watts G, Pedrow C (2003) Immunotoxin lesion of hypothalamically projecting norepinephrine and epinephrine neurons differentially affects circadian and stressor-stimulated corticosterone secretion. Endocrinology 144(4):1357-1367. doi: 10.1210/en.2002-221076 Summary: Hindbrain norepinephrine (NE) and epinephrine (E) neurons are important in the distribution of internal sensory signals. Injecting 42 ng of anti-DBH-SAP (Cat. #IT-03)

Immunotoxin lesion of hypothalamically projecting norepinephrine and epinephrine neurons differentially affects circadian and stressor-stimulated corticosterone secretion. Read More »

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