Author name: Kristen Hartman

Early microglial activation following neonatal excitotoxic brain damage in mice: a potential target for neuroprotection.

Dommergues MA, Plaisant F, Verney C, Gressens P (2003) Early microglial activation following neonatal excitotoxic brain damage in mice: a potential target for neuroprotection. Neuroscience 121(3):619-628. doi: 10.1016/s0306-4522(03)00558-x Summary: Brain lesions that mimic damage from cerebral palsy in mice are characterized by microglial activation within 24 hours of insult. Using intraperitoneal injections of Mac-1-SAP (90 […]

Early microglial activation following neonatal excitotoxic brain damage in mice: a potential target for neuroprotection. Read More »

Advanced Targeting Systems Awarded 2.4 Million Dollar SBIR Grant to Develop Revolutionary Chronic Pain Drug

SP SAP Drug Development /

San Diego, CA, October 7, 2003 – Advanced Targeting Systems, Inc. announced today that it has received a Small Business Innovative Research (SBIR) grant from the National Institute of Mental Health (NIMH) under the program announcement for pharmacologic agents and drugs to combat mental disorders. The three-year, $2.4 million award is a continuation of Phase

Advanced Targeting Systems Awarded 2.4 Million Dollar SBIR Grant to Develop Revolutionary Chronic Pain Drug Read More »

Targeting Tools: Rat-ZAP

News Tools /

Advanced Targeting Systems is pleased to announce the arrival of its newest second immunotoxin, Rat-ZAP (Cat. #IT-26). This new screening agent is constructed from goat anti-rat IgG conjugated to saporin. Like the other second immunotoxins, Hum-ZAP, Mab-ZAP and Rab-ZAP, it converts your primary antibody, in this case a rat IgG, into a potent cytotoxic agent

Targeting Tools: Rat-ZAP Read More »

Targeting Article: CCK-SAP in Binding Studies

News Article /

Our thanks to Drs. Frank Porecca, Victory Hruby and Josephine Lai, Department of Pharmacology, The University of Arizona Health Sciences Center for sharing the results of their studies. Cholecystokinin (CCK) is widely distributed in the central nervous system and the gastrointestinal tract. The 33-amino acid peptide contains a carboxyl terminal octapeptide sequence Asp-Tyr-Met-Gly-Trp-Met-Asp-Phe-NH2 which confers

Targeting Article: CCK-SAP in Binding Studies Read More »

Destruction of midbrain dopaminergic neurons by using an immunotoxin to the dopamine transporter.

Wiley RG, Harrison MB, Levey A, Lappi DA (2003) Destruction of midbrain dopaminergic neurons by using an immunotoxin to the dopamine transporter. Cell Mol Neurobiol 23:839-850. doi: 10.1023/a:1025065306264 Summary: The authors demonstrate the effective and specific removal of neurons expressing the dopamine transporter in the substantia nigra pars compacta and the ventral tegmental area with

Destruction of midbrain dopaminergic neurons by using an immunotoxin to the dopamine transporter. Read More »

Rostral ventrolateral medulla C1 neurons and cardiovascular regulation.

Madden CJ, Sved AF (2003) Rostral ventrolateral medulla C1 neurons and cardiovascular regulation. Cell Mol Neurobiol 23(4-5):739-749. doi: 10.1023/a:1025000919468 Summary: The authors review the use of anti-DBH-SAP (Cat. #IT-03) to study the role of C1 neurons within the rostral ventromedial medulla in cardiovascular regulation. This immunotoxin specifically removes C1 neurons containing dopamine beta-hydroxylase. Related Products:

Rostral ventrolateral medulla C1 neurons and cardiovascular regulation. Read More »

[Interaction between sensory and cognitive processes in visual recognition: the role of the associative areas of the cerebral cortex] Russian

Dudkin KN, Chueva IV, Makarov FN (2003) [Interaction between sensory and cognitive processes in visual recognition: the role of the associative areas of the cerebral cortex] Russian. Ross Fiziol Zh Im I M Sechenova 89(10):1226-1239. Summary: The authors used ME20.4-SAP(Cat. #IT-15). Related Products: ME20.4-SAP (Cat. #IT-15)

[Interaction between sensory and cognitive processes in visual recognition: the role of the associative areas of the cerebral cortex] Russian Read More »

S-nitrosating nitric oxide donors induce long-lasting inhibition of contraction in isolated arteries.

Alencar JL, Lobysheva I, Chalupsky K, Geffard M, Nepveu F, Stoclet JC, Muller B (2003) S-nitrosating nitric oxide donors induce long-lasting inhibition of contraction in isolated arteries. J Pharmacol Exp Ther 307(1):152-159. doi: 10.1124/jpet.103.052605 PMID: 12954813 Related Products: NO-L-Cysteine Mouse Monoclonal, Conjugated (Cat. #AB-T125)

S-nitrosating nitric oxide donors induce long-lasting inhibition of contraction in isolated arteries. Read More »

Featured Article: Subplate neurons and functional maturation of thalamocortical synapses

Kanold PO (2003) Featured Article: Subplate neurons and functional maturation of thalamocortical synapses. Targeting Trends 4(4) Related Products: ME20.4-SAP (Cat. #IT-15) Read the featured article in Targeting Trends. See Also: Kanold PO et al. Role of subplate neurons in functional maturation of visual cortical columns. Science 301(5632):521-525, 2003.

Featured Article: Subplate neurons and functional maturation of thalamocortical synapses Read More »

Search
Shopping Cart
Scroll to Top