Author name: Kristen Hartman

Role of subplate neurons in functional maturation of visual cortical columns.

Kanold PO, Kara P, Reid RC, Shatz CJ (2003) Role of subplate neurons in functional maturation of visual cortical columns. Science 301(5632):521-525. doi: 10.1126/science.1084152 Summary: Subplate neurons play a role in the development of connections between the thalamus and cerebral cortex. The authors used 0.5-µl injections of 0.25-1.0 mg/ml of ME20.4-SAP (Cat. #IT-15) to eliminate […]

Role of subplate neurons in functional maturation of visual cortical columns. Read More »

The role of the septo-hippocampal cholinergic projection in T-maze rewarded alternation.

Kirby BP, Rawlins JN (2003) The role of the septo-hippocampal cholinergic projection in T-maze rewarded alternation. Behav Brain Res 143(1):41-48. doi: 10.1016/s0166-4328(03)00005-6 Summary: 192-Saporin (Cat. #IT-01) has been used extensively to lesion cholinergic projections to the medial septum from the hippocampal region. It is not yet clear how post-lesion neural regeneration may affect the results.

The role of the septo-hippocampal cholinergic projection in T-maze rewarded alternation. Read More »

Targeting Tools: Targeting the Dopamine Transporter

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Advanced Targeting Systems announces the availability of two monoclonal antibodies to the dopamine transporter (DAT). These antibodies have become a standard for work on DAT and have already played a prominent role in the characterization of the dopamine transporter. The two antibodies are rat monoclonals, so they can be excellent for multiple staining protocols. Anti-DAT-NT, Cat.

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Substance P-Saporin (SP-SAP) Drug Development Update

SP SAP Drug Development /

Substance P-Saporin (SP-SAP) is under development as a chronic pain therapeutic with tremendous potential to permanently eliminate suffering in many painful diseases and conditions. ATS is awaiting news from the National Institutes of Health on further funding to fulfill FDA requirements to bring SP-SAP to clinical trial in humans. ATS has a patent on SP-SAP

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Cover Article: A New Immunotoxin for Targeting Dopaminergic Neurons

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Dopaminergic neurons are widely studied because of their role in one of the devastating diseases of old age, Parkinson’s. Lesioning studies using 6-hydroxydopamine or MPTP have been useful in research on Parkinson’s Disease. However, these reagents have limitations such as MPTP affecting catecholaminergic neurons and 6-OHDA stability and specificity issues. Targeting dopaminergic neurons with an

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Intrathecal substance p-saporin attenuates operant escape from nociceptive thermal stimuli.

Vierck CJ, Kline RH, Wiley RG (2003) Intrathecal substance p-saporin attenuates operant escape from nociceptive thermal stimuli. Neuroscience 119(1):223-232. doi: 10.1016/s0306-4522(03)00125-8 Summary: Administration of SP-SAP (Cat. #IT-07) eliminates sensitization of nocifensive reflexes. The authors investigate whether SP-SAP elimination of neurokinin-1 receptor-expressing neurons in the lumbar spinal cord affects nociceptive sensitivity in general, or preferentially affects

Intrathecal substance p-saporin attenuates operant escape from nociceptive thermal stimuli. Read More »

Neonatal 192 IgG-saporin lesion of forebrain cholinergic neurons: focus on the life span?

Pappas BA, Sherren N (2003) Neonatal 192 IgG-saporin lesion of forebrain cholinergic neurons: focus on the life span?. Neurosci Biobehav Rev 27(4):365-376. doi: 10.1016/s0149-7634(03)00067-8 Summary: In this review, the authors discuss the use of 192-Saporin in the investigation of neurodevelopmental disorders, and propose that the effects of these lesions are amplified as the animal ages

Neonatal 192 IgG-saporin lesion of forebrain cholinergic neurons: focus on the life span? Read More »

Lesions of the basal forebrain cholinergic system impair task acquisition and abolish cortical plasticity associated with motor skill learning.

Conner JM, Culberson A, Packowski C, Chiba AA, Tuszynski MH (2003) Lesions of the basal forebrain cholinergic system impair task acquisition and abolish cortical plasticity associated with motor skill learning. Neuron 38(5):819-829. doi: 10.1016/s0896-6273(03)00288-5 Summary: Neuronal plasticity has been associated with normal learning. The authors wished to investigate the role of the cholinergic basal forebrain

Lesions of the basal forebrain cholinergic system impair task acquisition and abolish cortical plasticity associated with motor skill learning. Read More »

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