Bailey AM, Rudisill ML, Hoof EJ, Loving ML (2003) 192 IgG-saporin lesions to the nucleus basalis magnocellularis (nBM) disrupt acquisition of learning set formation. Brain Res 969(1-2):147-159. doi: 10.1016/s0006-8993(03)02294-7
Summary: Previous studies by Bailey and others have used quisqualic acid to lesion the nucleus basalis (nBM) in order to understand Alzheimer’s disease. Injections of 75 ng of 192-Saporin (Cat. #IT-01) were made into each of four sites in the rat nBM. Behavioral tests showed initial learning set deficits followed by recovery, whereas with quisqualic acid lesions, the deficits were profound. The authors conclude noncholinergic neurons are involved in learning set formation.
Related Products: 192-IgG-SAP (Cat. #IT-01)