Wu M, Newton SS, Atkins JB, Xu C, Duman RS, Alreja M (2003) Acetylcholinesterase inhibitors activate septohippocampal GABAergic neurons via muscarinic but not nicotinic receptors. J Pharmacol Exp Ther 307(2):535-543. doi: 10.1124/jpet.103.052514 PMID: 12966162 Related Products: 192-IgG Mouse Monoclonal, Cy3-labeled (Cat. #AB-N43FL3)
Wiley RG, Lappi DA (2003) Targeted toxins in pain. Adv Drug Deliv Rev 55(8):1043-1054. doi: 10.1016/s0169-409x(03)00102-9 Summary: The authors discuss the use of ‘molecular neurosurgery’ in the study of nociception. Applications using targeted toxins, which include immunotoxins, protein-toxin conjugates, or peptide-toxin conjugates, are illustrated. The authors describe the use of these molecules as research tools,
Targeted toxins in pain. Read More »
Levita L, Mania I, Rainnie DG (2003) Subtypes of substance P receptor immunoreactive interneurons in the rat basolateral amygdala. Brain Res 981(1-2):41-51. doi: 10.1016/s0006-8993(03)02870-1 Summary: SP-SAP (Cat. #IT-07) has been used to lesion substance P receptor (SPr)-expressing neurons in the basolateral amygdala (BLA), but the interneuron subgroups targeted by SP-SAP in the BLA have not
Lehmann O, Grottick AJ, Cassel JC, Higgins GA (2003) A double dissociation between serial reaction time and radial maze performance in rats subjected to 192 IgG-saporin lesions of the nucleus basalis and/or the septal region. Eur J Neurosci 18(3):651-666. doi: 10.1046/j.1460-9568.2003.02745.x Summary: Using 0.4-µl injections containing 0.4 µg of 192-Saporin (Cat. #IT-01) into either the
Mistlberger RE, Antle MC, Kilduff TS, Jones M (2003) Food- and light-entrained circadian rhythms in rats with hypocretin-2-saporin ablations of the lateral hypothalamus. Brain Res 980(2):161-168. doi: 10.1016/s0006-8993(03)02755-0 Summary: Food-anticipatory behaviors in mammals can follow circadian rhythms entrained by daily feeding schedules. Lateral hypothalamic (LH) neurons express hypocretin (also known as orexin) receptors, therefore rats
Kanold PO, Kara P, Reid RC, Shatz CJ (2003) Role of subplate neurons in functional maturation of visual cortical columns. Science 301(5632):521-525. doi: 10.1126/science.1084152 Summary: Subplate neurons play a role in the development of connections between the thalamus and cerebral cortex. The authors used 0.5-µl injections of 0.25-1.0 mg/ml of ME20.4-SAP (Cat. #IT-15) to eliminate
Role of subplate neurons in functional maturation of visual cortical columns. Read More »
Kirby BP, Rawlins JN (2003) The role of the septo-hippocampal cholinergic projection in T-maze rewarded alternation. Behav Brain Res 143(1):41-48. doi: 10.1016/s0166-4328(03)00005-6 Summary: 192-Saporin (Cat. #IT-01) has been used extensively to lesion cholinergic projections to the medial septum from the hippocampal region. It is not yet clear how post-lesion neural regeneration may affect the results.
The role of the septo-hippocampal cholinergic projection in T-maze rewarded alternation. Read More »
Advanced Targeting Systems announces the availability of two monoclonal antibodies to the dopamine transporter (DAT). These antibodies have become a standard for work on DAT and have already played a prominent role in the characterization of the dopamine transporter. The two antibodies are rat monoclonals, so they can be excellent for multiple staining protocols. Anti-DAT-NT, Cat.
Targeting Tools: Targeting the Dopamine Transporter Read More »
Q: When performing intraparenchymal injections of immunotoxin, what is the proper volume to use? Is it better to induce two half-portions per hemisphere or is a higher concentration better? At what concentration do you expect necrosis or inflammation? A: There is no one answer to the question of injection volume. Practically speaking, we have observed
Dosing, Volume, and Animal Care Read More »
Lappi DA (2003) Featured Article: A new immunotoxin for targeting dopaminergic neurons. Targeting Trends 4(3) Related Products: Anti-DAT-SAP (Cat. #IT-25) Read the featured article in Targeting Trends.
Featured Article: A new immunotoxin for targeting dopaminergic neurons Read More »