Bagga S, Seth D, Batra JK (2003) The cytotoxic activity of ribosome-inactivating protein saporin-6 is attributed to its rRNA N-glycosidase and internucleosomal DNA fragmentation activities. J Biol Chem 278(7):4813-4820. doi: 10.1074/jbc.M207389200
Feldman JL, Mitchell GS, Nattie EE (2003) Breathing: Rhythmicity, Plasticity, Chemosensitivity. Annu Rev Neurosci 26:239-266. doi: 10.1146/annurev.neuro.26.041002.131103 Summary: Recent research has indicated that specific areas of the brain exert control over several aspects of breathing, such as rhythm generation, reaction to hypoxia, and regulation of carbon dioxide levels and pH. This review covers many of
Breathing: Rhythmicity, Plasticity, Chemosensitivity. Read More »
Lamprea MR, Cardenas FP, Silveira R, Walsh TJ, Morato S (2003) Effects of septal cholinergic lesion on rat exploratory behavior in an open-field. Braz J Med Biol Res 36(2):233-238. doi: 10.1590/s0100-879×2003000200011 Summary: Exploratory behavior triggered by novelty involves the medial septum. The authors lesioned the medial septum in rats with 237.5-ng injections of 192-Saporin (Cat.
Effects of septal cholinergic lesion on rat exploratory behavior in an open-field. Read More »
Kennedy AD, Solga MD, Schuman TA, Chi AW, Lindorfer MA, Sutherland WM, Foley PL, Taylor RP (2003) An anti-C3b(i) mAb enhances complement activation, C3b(i) deposition, and killing of CD20+ cells by rituximab. Blood 101(3):1071-1079. doi: 10.1182/blood-2002-03-0876 PMID: 12393727 Related Products: Antibody to Complement C3 (3E7) (Cat. #AB-V82)
Birthelmer A, Ehret A, Amtage F, Förster S, Lehmann O, Jeltsch H, Cassel JC, Jackisch R (2003) Neurotransmitter release and its presynaptic modulation in the rat hippocampus after selective damage to cholinergic or/and serotonergic afferents. Brain Res Bull 59(5):371-381. doi: 10.1016/s0361-9230(02)00930-9 Summary: Previous studies have investigated some of the modulatory mechanisms present in the denervated
Gerashchenko K, Blanco-Centurion C, Greco MA, Shiromani PJ (2003) Effects of lateral hypothalamic lesion with the neurotoxin hypocretin-2-saporin on sleep in Long-Evans rats. Neuroscience 116:223-235. doi: 10.1016/s0306-4522(02)00575-4 Summary: Recent data has linked narcolepsy to the loss of neurons containing the neuropeptide hypocretin, also known as orexin. The authors wished to investigate whether the variance in
Even though it only became available recently, Dermorphin-SAP (Cat. #IT-12) has already begun to help researchers unlock the mysteries of brain function. Dermorphin-SAP is a chemical conjugate between an analog of the frog skin peptide dermorphin and the ribosome- inactivating protein saporin. Dermorphin, a peptide of seven amino acids characterized by Ersparmer and his colleagues,1
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Q: How do I know my peptide will work as a targeted toxin? A: There is rich literature that demonstrates peptides can usher proteins that inhibit protein synthesis (such as saporin) into cells and result in cell death. Peptide ligands that bind to the cell surface (i.e., to their receptors) are internalized-in fact, often quite
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Truitt W (2003) Featured Article: Deep lumbar neurons control ejaculation. Targeting Trends 4(1) Related Products: SSP-SAP (Cat. #IT-11) Read the featured article in Targeting Trends. See Also: Truitt WA et al. Lesions Of Spinothalamic Neurons In Lumbar Spinal Cord Disrupt Ejaculatory Reflexes In Male Rats. Neuroscience 2002 Abstracts 69.2, 2002. Society for Neuroscience, Orlando, FL
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Advanced Targeting Systems continues to search for funding to develop Substance P-Saporin (SP-SAP) as a chronic pain therapeutic. In May of last year we decided to seek venture capital funding and began traveling to make presentations to potential investors. The response from most everyone we spoke to was positive and they thought the potential of
SP-SAP as a Chronic Pain Therapeutic: An Update Read More »