Mistlberger RE, Antle MC, Kilduff TS, Jones M (2003) Food- and light-entrained circadian rhythms in rats with hypocretin-2-saporin ablations of the lateral hypothalamus. Brain Res 980(2):161-168. doi: 10.1016/s0006-8993(03)02755-0
Summary: Food-anticipatory behaviors in mammals can follow circadian rhythms entrained by daily feeding schedules. Lateral hypothalamic (LH) neurons express hypocretin (also known as orexin) receptors, therefore rats were treated with four 500-ng injections of orexin-SAP (Cat. #IT-20) to eliminate these neurons. Lesioned animals displayed altered dietary behavior, but maintained anticipatory activity before the daily meal.
Related Products: Orexin-B-SAP (Cat. #IT-20)