Author name: Kristen Hartman

Antibody-drug conjugates plus Janus kinase inhibitors enable MHC-mismatched allogeneic hematopoietic stem cell transplantation

Persaud SP, Ritchey JK, Kim S, Lim S, Ruminski PG, Cooper ML, Rettig MP, Choi J, DiPersio JF (2021) Antibody-drug conjugates plus Janus kinase inhibitors enable MHC-mismatched allogeneic hematopoietic stem cell transplantation. J Clin Invest 131(24):e145501. doi: 10.1172/JCI145501 Objective: To demonstrate that biotinylated anti-CD45-SAP or anti-cKit-SAP mixed with Streptavidin-Saporin along with Janus kinase 1/2, enables […]

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Basal forebrain cholinergic neurons selectively drive coordinated motor learning in mice

Li Y, Hollis E (2021) Basal forebrain cholinergic neurons selectively drive coordinated motor learning in mice. J Neurosci 41(49):10148-10160. doi: 10.1523/JNEUROSCI.1152-21.2021 PMID: 34750228 Related Products: NGFr (mu p75) Rabbit Polyclonal, affinity-purified (Cat. #AB-N01AP), mu p75-SAP (Cat. #IT-16)

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Converting extracellular vesicles into nanomedicine: loading and unloading of cargo

Joshi BS, Ortiz D, Zuhorn IS (2021) Converting extracellular vesicles into nanomedicine: loading and unloading of cargo. Materials Today Nano 16:100148. doi: 10.1016/j.mtnano.2021.100148 Objective: To provide a comprehensive overview of (i) methods for the loading of EVs with therapeutic cargo, (ii) methods for EV surface functionalization to direct EVs to target cells, and (iii) methods

Converting extracellular vesicles into nanomedicine: loading and unloading of cargo Read More »

Perspective: Estrogen and the risk of cognitive decline: a missing choline(rgic) link?

Bortz J, Klatt KC, Wallace TC (2021) Perspective: Estrogen and the risk of cognitive decline: a missing choline(rgic) link?. Adv Nutr 13(2):376-387. doi: 10.1093/advances/nmab145 Objective: Explore the relationship between cognitive aging and sex hormones, the cholinergic system, and choline as an essential nutrient. Summary: This perspective identifies numerous areas for future preclinical and clinical research,

Perspective: Estrogen and the risk of cognitive decline: a missing choline(rgic) link? Read More »

The molecular basis for IL-31 production and IL-31-mediated itch transmission: from biology to drug development

Kunimura K, Fukui Y (2021) The molecular basis for IL-31 production and IL-31-mediated itch transmission: from biology to drug development. Int Immunol 33(12):731-736. doi: 10.1093/intimm/dxab065 Objective: To investigate the molecular mechanisms of how IL-31 is produced in helper T cells upon stimulation and transmits the itch sensation to the brain. Summary: This review highlights recent

The molecular basis for IL-31 production and IL-31-mediated itch transmission: from biology to drug development Read More »

Mitochondrial aspartate regulates TNF biogenesis and autoimmune tissue inflammation.

Wu B, Zhao TV, Jin K, Hu Z, Abdel MP, Warrington KJ, Goronzy JJ, Weyand CM (2021) Mitochondrial aspartate regulates TNF biogenesis and autoimmune tissue inflammation. Nat Immunol 22(12):1551-1562. doi: 10.1038/s41590-021-01065-2 Objective: To identify a deficiency of mitochondrial aspartate production as a key abnormality in autoimmune T cells. Summary: Shortage of mitochondrial aspartate disrupted the

Mitochondrial aspartate regulates TNF biogenesis and autoimmune tissue inflammation. Read More »

Vagal afferent cholecystokinin receptor activation is required for glucagon-like peptide-1-induced satiation

Vana V, Laerke MK, Rehfeld JF, Arnold M, Dmytriyeva O, Langhans W, Schwartz TW, Hansen HS (2022) Vagal afferent cholecystokinin receptor activation is required for glucagon-like peptide-1-induced satiation. Diabetes Obes Metab 24(2):268-280. doi: 10.1111/dom.14575 Objective: To investigate the effect of peripheral GLP-1 on food-intake control. Summary: Endogenous CCK interacts with GLP-1 to promote satiation and

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Hypertensive effects of transforming growth factor-β1 in vascular smooth muscles cells from spontaneously hypertensive rats are mediated by sulfatase 2

Kim HS, Kim HY (2022) Hypertensive effects of transforming growth factor-β1 in vascular smooth muscles cells from spontaneously hypertensive rats are mediated by sulfatase 2. Cytokine 150:155754. doi: 10.1016/j.cyto.2021.155754 PMID: 34808537 Objective: To examine the role of extracellular sulfatases on TGF-β1-induced effects associated with the expression of mediators related to hypertension in vascular smooth muscle

Hypertensive effects of transforming growth factor-β1 in vascular smooth muscles cells from spontaneously hypertensive rats are mediated by sulfatase 2 Read More »

Intrahippocampal adeno-associated virus-mediated overexpression of nerve growth factor reverses 192IgG-saporin-induced impairments of hippocampal plasticity and behavior

Dobryakova YV, Spivak YS, Zaichenko MI, Koryagina AA, Markevich VA, Stepanichev MY, Bolshakov AP (2021) Intrahippocampal adeno-associated virus-mediated overexpression of nerve growth factor reverses 192IgG-saporin-induced impairments of hippocampal plasticity and behavior. Front Neurosci 15:745050. doi: 10.3389/fnins.2021.745050 Objective: Determine any beneficial effects of adeno-associated virus (AAV)-mediated overexpression of nerve growth factor (NGF) in the hippocampus of

Intrahippocampal adeno-associated virus-mediated overexpression of nerve growth factor reverses 192IgG-saporin-induced impairments of hippocampal plasticity and behavior Read More »

Enhancing the therapeutic potential of extracellular vesicles using peptide technology

Martin Perez C, Conceição M, Raz R, Wood MJA, Roberts TC (2022) Enhancing the therapeutic potential of extracellular vesicles using peptide technology. (eds. Langel Ü). In: Cell Penetrating Peptides. Methods in Molecular Biology 2383:119-141. Humana, New York, NY. doi: 10.1007/978-1-0716-1752-6_8 Objective: To modify EVs with peptides which confer specific advantageous properties, thus enhancing their therapeutic

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