Author name: Kristen Hartman

Streptavidin-drug conjugates streamline optimization of antibody-based conditioning for hematopoietic stem cell transplantation

Yelamali AR, Chendamarai E, Ritchey JK, Rettig MP, DiPersio JF, Persaud SP (2024) Streptavidin-drug conjugates streamline optimization of antibody-based conditioning for hematopoietic stem cell transplantation. bioRxiv 2024.02.12.579199. doi: 10.1101/2024.02.12.579199 PMID: 38405731 Objective: Use biotinylated CD45.2 antibodies conjugated to Streptavidin to target hematopoietic stem cells (HSCs) for HSC transplantation. Summary: Hematopoietic stem cell transplantation offers a […]

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Targeted drug delivery using nanobodies to deliver effective molecules to breast cancer cells: The most attractive application of nanobodies

Abdolvahab MH, Karimi P, Mohajeri N, Abedini M, Zare H (2024) Targeted drug delivery using nanobodies to deliver effective molecules to breast cancer cells: The most attractive application of nanobodies. Cancer Cell Int 24(1):67. doi: 10.1186/s12935-024-03259-8 PMID: 38341580 Objective: Using nanobodies to deliver saporin to breast cancer cells. Summary: Through the binding of saporin to

Targeted drug delivery using nanobodies to deliver effective molecules to breast cancer cells: The most attractive application of nanobodies Read More »

The effect of NK3-Saporin injection within the arcuate nucleus on puberty, the LH surge, and the response to Senktide in female sheep

Aerts EG, Griesgraber MJ, Shuping SL, Bowdridge EC, Hardy SL, Goodman RL, Nestor CC, Hileman SM (2024) The effect of NK3-Saporin injection within the arcuate nucleus on puberty, the LH surge, and the response to Senktide in female sheep. Biol Reprod 110(2):275-287. doi: 10.1093/biolre/ioad147 PMID: 37930247 Objective: To investigate the role of NKB-SAP (NK3-SAP) in

The effect of NK3-Saporin injection within the arcuate nucleus on puberty, the LH surge, and the response to Senktide in female sheep Read More »

Investigating the cytosolic delivery of proteins by lipid nanoparticles using the chloroalkane penetration assay

Wang J, Zhang S, Li Y, Xu Q, Kritzer JA (2024) Investigating the cytosolic delivery of proteins by lipid nanoparticles using the chloroalkane penetration assay. Biochemistry 63(4):512-522. doi: 10.1021/acs.biochem.3c00614 PMID: 38334719 Objective: To investigate bovine serum albumin (BSA) protein encapsulation and release within polylysine/polyglutamate (PLys/PGlu) coacervates. Summary: The findings emphasize the importance of ingredient addition

Investigating the cytosolic delivery of proteins by lipid nanoparticles using the chloroalkane penetration assay Read More »

Retinal response to systemic inflammation differs between sexes and neurons

Rodríguez-Ramírez KT, Norte-Muñoz M, Lucas-Ruiz F, Gallego-Ortega A, Calzaferri F, García-Bernal D, Martínez CM, Galindo-Romero C, de Los Ríos C, Vidal-Sanz M, Agudo-Barriuso M (2024) Retinal response to systemic inflammation differs between sexes and neurons. Front Immunol 15:1340013. doi: 10.3389/fimmu.2024.1340013 PMID: 38384465 Objective: To examine how systemic inflammation, induced by intraperitoneal administration of lipopolysaccharide (LPS),

Retinal response to systemic inflammation differs between sexes and neurons Read More »

Efficacy and specificity of melanopsin reporters for retinal ganglion cells

Maloney R, Quattrochi L, Yoon J, Souza R, Berson D (2024) Efficacy and specificity of melanopsin reporters for retinal ganglion cells. J Comp Neurol 532(2):e25591. doi: 10.1002/cne.25591 PMID: 38375612 Objective: To evaluate the precision and comprehensiveness of various labeling methods for intrinsically photosensitive retinal ganglion cells (ipRGCs). Summary: The authors provide a comparative analysis of

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Cell lipotypes localization in brain by mass spectrometry imaging

Martínez-Gardeazabal J, Moreno-Rodríguez M, Llorente-Ovejero A, González de San Román E, Lombardero L, Bengoetxea de Tena I, Sustacha J, Matute C (2024) Cell lipotypes localization in brain by mass spectrometry imaging. bioRxiv 2024.02.02.578599. doi: 10.1101/2024.02.02.578599 Objective: Characterizing the type of different central nervous system cells via mass spectrometry of their component lipids. Summary: Different varieties

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Cadherin-13 Maintains Retinotectal Synapses via Transneuronal Interactions

Matcham AC, Toma K, Tsai NY, Sze CJ, Lin PY, Stewart IF, Duan X (2024) Cadherin-13 Maintains Retinotectal Synapses via Transneuronal Interactions. J Neurosci 44(5):e1310232023. doi: 10.1523/JNEUROSCI.1310-23.2023 PMID: 38123991 Objective: To explore the role of Type II cadherins, particularly Cdh13, in the formation of specific retinotectal synapses. Summary: Cdh13 is highly expressed in wide-field neurons

Cadherin-13 Maintains Retinotectal Synapses via Transneuronal Interactions Read More »

Brainstem C1 neurons mediate heart failure decompensation and mortality during acute salt loading

Schwarz KG, Pereyra KV, Diaz-Jara E, Vicencio SC, Del Rio R (2025) Brainstem C1 neurons mediate heart failure decompensation and mortality during acute salt loading. Cardiovascular Research 121(2):241-253. doi: 10.1093/cvr/cvae261 PMID: 39775485 Objective: To test whether rostral ventrolateral medulla (RVLM) C1 neurons drive cardiorespiratory decompensation, and ultimately lead to sudden death in heart failure (HF)

Brainstem C1 neurons mediate heart failure decompensation and mortality during acute salt loading Read More »

The basal forebrain cholinergic system as target for cell replacement therapy in Parkinson’s disease

Björklund A, Barker RA (2024) The basal forebrain cholinergic system as target for cell replacement therapy in Parkinson’s disease. Brain awae026. doi: 10.1093/brain/awae026 PMID: 38279949 Objective: Review the use of cholinergic cell replacement as a potential therapeutic strategy in Parkinson’s Disease (PD) and how rodent models of PD-like cognitive decline can be used by analyzing

The basal forebrain cholinergic system as target for cell replacement therapy in Parkinson’s disease Read More »

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