Hua C, Qiu L (2024) Polymersomes for therapeutic protein and peptide delivery: Towards better loading properties. Int J Nanomedicine 19:2317-2340. doi: 10.2147/IJN.S444910 PMID: 38476284
Objective: To highlight the potential of polymersomes as the next-generation therapeutic proteins and peptides carrier and to introduce novel approaches and recent progress to achieve satisfactory encapsulation capability of polymersomes for proteins and peptides.
Summary: With the help of intermolecular interactions, such as electrostatic, lipid–protein, and hydrophobic interactions, the drug loading could be significantly improved. Loading improvement could be attained through innovation of preparation methods, ranging from modified traditional film hydration techniques to the novel phase-guided assembly method.
Usage: Effective inhibition of tumor growth was observed in saporin-loaded polymersomes. Mice treated with this formulation experienced a significant extension in median survival time (50 d) compared to PBS (28 d).
Related Products: Saporin (Cat. #PR-01)
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