Functions and mechanisms of adenosine and its receptors in sleep regulation

Huang L, Zhu W, Li N, Zhang B, Dai W, Li S, Xu H (2024) Functions and mechanisms of adenosine and its receptors in sleep regulation. Sleep Med 115:210-217. doi: 10.1016/j.sleep.2024.02.012 PMID: 38373361

Objective: To summarize the current research on the functions and possible mechanisms of adenosine and its receptors in regulating sleep and homeostatic control of sleep.

Summary: Authors concluded that the adenosine A1 receptor regulates sleep homeostasis by micro dialysis perfusion of antisense oligonucleotides against the RNA of the A1 Receptor in the magnocellular cholinergic region of the basal forebrain of a freely behaving rat. Adenosine has certain physiological significance in circadian rhythm, energy homeostasis, and sleep.

Usage: Loss of cholinergic cells was associated with a significant increase in sleep deprivation-induced adenosine level in the BF and a perfectly homeostatic sleep response.

Related Products: 192-IgG-SAP (Cat. #IT-01)

See Also:

• Kalinchuk AV et al. The role of cholinergic basal forebrain neurons in adenosine-mediated homeostatic control of sleep: lessons from 192 IgG-saporin lesions. Neuroscience 157:238-253, 2008.