Author name: Kristen Hartman

Selective medial septum lesions in healthy rats induce longitudinal changes in microstructure of limbic regions, behavioral alterations, and increased susceptibility to status epilepticus

Luna-Munguia H, Gasca-Martinez D, Garay-Cortes A, Coutiño D, Regalado M, de Los Rios E, Villaseñor P, Hidalgo-Flores F, Flores-Guapo K, Benito BY, Concha L (2024) Selective medial septum lesions in healthy rats induce longitudinal changes in microstructure of limbic regions, behavioral alterations, and increased susceptibility to status epilepticus. Mol Neurobiol 61(10):1-21. doi: 10.1007/s12035-024-04069-9 PMID: 38443731 […]

Selective medial septum lesions in healthy rats induce longitudinal changes in microstructure of limbic regions, behavioral alterations, and increased susceptibility to status epilepticus Read More »

Advances in HIV gene therapy

Kitawi R, Ledger S, Kelleher AD, Ahlenstiel CL (2024) Advances in HIV gene therapy. Int J Mol Sci 25(5):2771. doi: 10.3390/ijms25052771 PMID: 38474018 Objective: This review highlights the various stages of ex vivo gene therapy, current research developments that have increased the efficiency and safety of this process, and a comprehensive summary of Human Immunodeficiency

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Therapeutic peptides and proteins: Stabilization challenges and biomedical applications by means of nanodelivery systems

Berselli E, Coccolini C, Tosi G, Gokce EH, Oliveira MBPP, Fathi F, Krambeck K, Suoto EB (2024) Therapeutic peptides and proteins: Stabilization challenges and biomedical applications by means of nanodelivery systems. Int J Pept Res Ther 30:15. doi: 10.1007/s10989-024-10592-z Objective: To discuss the stability problems of proteins and peptides that have driven the scientific community

Therapeutic peptides and proteins: Stabilization challenges and biomedical applications by means of nanodelivery systems Read More »

NGFR regulates stromal cell activation in germinal centers

Hernández-Barranco A, Santos V, Mazariegos MS, Caleiras E, Nogués L, Mourcin F, Léonard S, Oblet C, Genebrier S, Rossille D, Benguría A, Sanz A, Vázquez E, Dopazo A, Efeyan A, Ortega-Molina A, Cogne M, Tarte K, Peinado H (2024) NGFR regulates stromal cell activation in germinal centers. Cell Rep 43(2):113705. doi: 10.1016/j.celrep.2024.113705 PMID: 38307025 Objective:

NGFR regulates stromal cell activation in germinal centers Read More »

Engineering small protein based inhibitors and biodegraders for cytosolic delivery and targeting of the undruggable proteome

Chan A (2024) Engineering small protein based inhibitors and biodegraders for cytosolic delivery and targeting of the undruggable proteome. Univ Pennsylvania Thesis. Objective: Studying the delivery of saporin across the cell membrane encapsulated in lipid nanoparticles. Summary: Protein payloads, like saporin and others, are given negatively charged regions which create binding sites for cationic lipids

Engineering small protein based inhibitors and biodegraders for cytosolic delivery and targeting of the undruggable proteome Read More »

Women’s special issue series: Biomedicines

Polito L (2024) Women’s special issue series: Biomedicines. Biomedicines 12(3):471. doi: 10.3390/biomedicines12030471 PMID: 38540085 Summary: Saporin is a single-chain ribosome-inactivating protein (RIP) with low toxicity in cells and animals. When the protein is linked to a carrier that facilitates cellular uptake, the protein can become highly and selectively toxic to the cellular target of the

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Reduced alcohol consumption following ablation of cholinergic interneurons in the nucleus accumbens of wistar rats

Loftén A, Cadeddu D, Danielsson K, Stomberg R, Adermark L, Söderpalm B, Ericson M (2024) Reduced alcohol consumption following ablation of cholinergic interneurons in the nucleus accumbens of wistar rats. Addict Biol 30(2):e70022. doi: 10.1111/adb.70022 PMID: 39936333 Objective: The aim of this study was to explore the functional role of accumbal Cholinergic interneurons (CIN) in

Reduced alcohol consumption following ablation of cholinergic interneurons in the nucleus accumbens of wistar rats Read More »

Superoxide dismutase 2 deficiency is associated with enhanced central chemoreception in mice: Implications for breathing regulation

Díaz-Jara E, Pereyra K, Vicencio S, Olesen MA, Schwarz KG, Toledo C, Díaz HS, Quintanilla RA, Del Rio R (2024) Superoxide dismutase 2 deficiency is associated with enhanced central chemoreception in mice: Implications for breathing regulation. Redix Biol 69:102992. doi: 10.1016/j.redox.2023.102992 PMID: 38142585 Objective: To determine the impact of partial deletion of SOD2 expression on

Superoxide dismutase 2 deficiency is associated with enhanced central chemoreception in mice: Implications for breathing regulation Read More »

Brainstem DBH+ neurons control chronic allergen-induced airway hyperreactivity

Su Y, Xu J, Zhu Z, Chin J, Xu L, Yu H, Nudell V, Dash B, Moya EA, Ye L, Nammerjahn A, Sun X (2024) Brainstem DBH+ neurons control chronic allergen-induced airway hyperreactivity. bioRxiv 2023.02.04.527145. doi: 10.1101/2023.02.04.527145 PMID: 36778350 Summary: The authors show that a single population of Dbh+ neurons in the nucleus of the

Brainstem DBH+ neurons control chronic allergen-induced airway hyperreactivity Read More »

Streptavidin-drug conjugates streamline optimization of antibody-based conditioning for hematopoietic stem cell transplantation

Yelamali AR, Chendamarai E, Ritchey JK, Rettig MP, DiPersio JF, Persaud SP (2024) Streptavidin-drug conjugates streamline optimization of antibody-based conditioning for hematopoietic stem cell transplantation. bioRxiv 2024.02.12.579199. doi: 10.1101/2024.02.12.579199 PMID: 38405731 Objective: Use biotinylated CD45.2 antibodies conjugated to Streptavidin to target hematopoietic stem cells (HSCs) for HSC transplantation. Summary: Hematopoietic stem cell transplantation offers a

Streptavidin-drug conjugates streamline optimization of antibody-based conditioning for hematopoietic stem cell transplantation Read More »

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