Author name: Kristen Hartman

Substance P-botulinum mediates long-term silencing of pain pathways that can be re-instated with a second injection of the construct in mice

Maiarù M, Leese C, Silva-Hucha S, Fontana-Giusti S, Tait L, Tamagnini F, Davletov B, Hunt SP (2024) Substance P-botulinum mediates long-term silencing of pain pathways that can be re-instated with a second injection of the construct in mice. J Pain 25(6):104466. doi: 10.1016/j.jpain.2024.01.331 PMID: 38218509 Summary: The authors discuss how Substance P-Botulinum is used to […]

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New methods to investigate the GnRH pulse generator

Ivanova D, O’Byrne KT (2024) New methods to investigate the GnRH pulse generator. J Mol Endocrinol 72(2):e230079. doi: 10.1530/JME-23-0079 PMID: 38085702 Objective: To review the latest methodologies and insights into the GnRH pulse generator and its role in regulating reproductive hormone secretion. Summary: The paper discusses recent advancements in understanding the GnRH pulse generator and

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Separate gut-brain circuits for fat and sugar reinforcement combine to promote overeating

McDougle M, de Araujo A, Singh A, Yang M, Braga I, Paille V, Mendez-Hernandez R, Vergara M, Woodie LN, Gour A, Sharma A, Urs N, Warren B, de Lartigue G (2024) Separate gut-brain circuits for fat and sugar reinforcement combine to promote overeating. Cell Metab 36:1-15. doi: 10.1016/j.cmet.2023.12.014 PMID: 38242133 Objective: To investigate the separate

Separate gut-brain circuits for fat and sugar reinforcement combine to promote overeating Read More »

Preservation of intrinsically photosensitive retinal ganglion cells (ipRGCs) in late adult mice: Implications as a potential biomarker for early onset ocular degenerative diseases

Matynia A, Recio BS, Myers Z, Parikh S, Goit RK, Brecha NC, Pérez de Sevilla Müller L (2024) Preservation of intrinsically photosensitive retinal ganglion cells (ipRGCs) in late adult mice: Implications as a potential biomarker for early onset ocular degenerative diseases. Invest Ophthalmol Vis Sci 65(1):28. doi: 10.1167/iovs.65.1.28 PMID: 38224335 Objective: To assess the preservation

Preservation of intrinsically photosensitive retinal ganglion cells (ipRGCs) in late adult mice: Implications as a potential biomarker for early onset ocular degenerative diseases Read More »

Endosialin in cancer: Expression patterns, mechanistic insights, and therapeutic approaches

Lu S, Gan L, Lu T, Zhang K, Zhang J, Wu X, Han D, Xu C, Liu S, Yang F, Qin W, Wen W (2024) Endosialin in cancer: Expression patterns, mechanistic insights, and therapeutic approaches. Theranostics 14(1):379-391. doi: 10.7150/thno.89495 PMID: 38164138 Objective: To discuss the use of a saporin conjugate to 78Fc, an antibody fragment

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Self-assembly of epitope-tagged proteins and antibodies for delivering biologics to antigen presenting cells

Gong S, Qiu J, Thayumanavan S (2024) Self-assembly of epitope-tagged proteins and antibodies for delivering biologics to antigen presenting cells. J Am Chem Soc 146(1):33-38. doi: 10.1021/jacs.3c09334 PMID: 38147631 Objective: To describe a simple self-assembly strategy for generating artificial immune complexes. Summary: The built-in recognition domains in the antibody, viz. the Fab and Fc domains,

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Neural mechanisms responsible for vagus nerve stimulation-dependent enhancement of somatosensory recovery

Malley KM, Ruiz AD, Darrow MJ, Danaphongse TT, Shiers S, Ahmad FN, Mota Beltran C, Stanislav BT, Rennaker II RL, Kilgard MP, Hays SA (2023) Neural mechanisms responsible for vagus nerve stimulation-dependent enhancement of somatosensory recovery. SSRN doi: 10.2139/ssrn.4662058 Objective: Optimizing and identifying mechanism of curative action in Vagus Nerve Stimulation therapy on a model

Neural mechanisms responsible for vagus nerve stimulation-dependent enhancement of somatosensory recovery Read More »

Heterophyllin: A new adenia toxic lectin with peculiar biological properties

Bortolotti M, Biscotti F, Zanello A, Polito L, Bolognesi A (2024) Heterophyllin: A new adenia toxic lectin with peculiar biological properties. Toxins 16(1):1. doi: 10.3390/toxins16010001 PMID: 38276525 Objective: Describe the novel type II Ribosome Inactivating Protein, Heterophyllin. Summary: Heterophyllin, a novel toxic lectin from Adenia heterophylla shows enzymatic and lectin properties of type 2 RIPs.

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Intracellular protein delivery: Approaches, challenges, and clinical applications

Chan A, Tsourkas A (2024) Intracellular protein delivery: Approaches, challenges, and clinical applications. BME Frontiers 5:0035. doi: 10.34133/bmef.0035 PMID: 38282957 Objective: To review progress made towards achieving cytosolic delivery of recombinant proteins and possible strategies to enable proteins to cross cell membranes. Summary: Drug delivery researchers have worked to deliver saporin into tumor cells in

Intracellular protein delivery: Approaches, challenges, and clinical applications Read More »

Immunomodulatory impact of memory T lymphocyties in periodontitis

de Paula FS (2023) Immunomodulatory impact of memory T lymphocyties in periodontitis. Univ Minnesota Thesis. Objective: This thesis paper sought to determine whether local reactivation of oral tissue resident memory cells (TRM) of a defined antigen specificity could exacerbate ligature-induced periodontal (LIP), a model for periodontal disease in mice. Summary: Reactivation of oral TRM aggravated

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