Schwarz KG, Pereyra KV, Diaz-Jara E, Vicencio SC, Del Rio R (2024) Brainstem C1 neurons mediate heart failure decompensation and mortality during acute salt loading. Cardiovascular Research doi: 10.1093/cvr/cvae261 PMID: 39775485
Objective: To test whether rostral ventrolateral medulla (RVLM) C1 neurons drive cardiorespiratory decompensation, and ultimately lead to sudden death in heart failure (HF) rats.
Summary: The results strongly suggest that RVLM C1 neurons contribute to acute HF decompensation during salt loading by a mechanism encompassing further increases in sympathetic outflow and hypoxia-related breathing disorder.
Usage: Bilateral injections of anti-dopamine-β-hydroxylase conjugated with saporin toxin (Anti-DBH-SAP; 7.5 ng/100 nl of sterile saline solution) were delivered to the RVLM-C1 region using the stereotaxic coordinates.
Related Products: Anti-DBH-SAP (Cat. #IT-03)