Bortz J, Klatt KC, Wallace TC (2021) Perspective: Estrogen and the risk of cognitive decline: a missing choline(rgic) link?. Adv Nutr 13(2):376-387. doi: 10.1093/advances/nmab145
Objective: Explore the relationship between cognitive aging and sex hormones, the cholinergic system, and choline as an essential nutrient.
Summary: This perspective identifies numerous areas for future preclinical and clinical research, highlighting the need for randomized controlled trials in postmenopausal women to assess the impact of choline supplementation on cognitive decline, with appropriate consideration of the estrogen availability, critical windows, dose, and PEMT genotype.
Usage: The authors reference a publication about the effects of estrogen on cognitive improvements where 192-IgG-SAP was used as a specific cholinergic system lesioning tool.
Related Products: 192-IgG-SAP (Cat. #IT-01)
See Also:
- Gibbs RB Basal forebrain cholinergic neurons are necessary for estrogen to enhance acquisition of a delayed matching-to-position T-maze task. Horm Behav 42(3):245-257, 2002.
- Gibbs RB et al. Donepezil plus estradiol treatment enhances learning and delay-dependent memory performance by young ovariectomized rats with partial loss of septal cholinergic neurons. Horm Behav 59(4):503-511, 2011.