Kunimura K, Fukui Y (2021) The molecular basis for IL-31 production and IL-31-mediated itch transmission: from biology to drug development. Int Immunol 33(12):731-736. doi: 10.1093/intimm/dxab065
Objective: To investigate the molecular mechanisms of how IL-31 is produced in helper T cells upon stimulation and transmits the itch sensation to the brain.
Summary: This review highlights recent findings that show the functional significance of endothelial PAS domain 1 (EPAS1) and neurokinin B (NKB) in the IL-31-induced itch sensation.
Usage: Neurons expressing the Nppb receptor were specifically ablated by intrathecal injection of Nppb-SAP. Treatment with Bombesin-SAP reduced IL-31-induced scratching.