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Vagal afferent cholecystokinin receptor activation is required for glucagon-like peptide-1-induced satiation

Vana V, Laerke MK, Rehfeld JF, Arnold M, Dmytriyeva O, Langhans W, Schwartz TW, Hansen HS (2022) Vagal afferent cholecystokinin receptor activation is required for glucagon-like peptide-1-induced satiation. Diabetes Obes Metab 24(2):268-280. doi: 10.1111/dom.14575

Objective: To investigate the effect of peripheral GLP-1 on food-intake control.

Summary: Endogenous CCK interacts with GLP-1 to promote satiation and that activation of the FFA1 receptor can initiate this interaction by stimulating the release of CCK.

Usage: Utilized CCK-SAP to selectively ablate the CCK receptor-expressing gastrointestinal vagal afferent neurones (VANs).

Related Products: CCK-SAP (Cat. #IT-31)