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Intrahippocampal adeno-associated virus-mediated overexpression of nerve growth factor reverses 192IgG-saporin-induced impairments of hippocampal plasticity and behavior

Dobryakova YV, Spivak YS, Zaichenko MI, Koryagina AA, Markevich VA, Stepanichev MY, Bolshakov AP (2021) Intrahippocampal adeno-associated virus-mediated overexpression of nerve growth factor reverses 192IgG-saporin-induced impairments of hippocampal plasticity and behavior. Front Neurosci 15:745050. doi: 10.3389/fnins.2021.745050

Objective: Determine any beneficial effects of adeno-associated virus (AAV)-mediated overexpression of nerve growth factor (NGF) in the hippocampus of rats with cholinergic loss.

Summary: 192-IgG-SAP was used to induce a rat animal model of cholinergic deficit. The authors concluded that NGF overexpression in the hippocampus after cholinergic loss induces beneficiall effects which are not related to maintenance of cholinergic function.

Usage: 1.5 mg of 192-IgG-SAP was injected into the medial septum area.

Related Products: 192-IgG-SAP (Cat. #IT-01)

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