Hess PR, Buntzman AS, Murray SL, Young EF, Frelinger JA (2009) Featured Article: Selective deletion of CD8+ T cells by saporin-coupled MHC class I tetramers. Targeting Trends 10(1) Related Products: Streptavidin-ZAP (Cat. #IT-27), Saporin Goat Polyclonal, affinity-purified FITC-labeled (Cat. #AB-15APFL) Read the featured article in Targeting Trends. See Also: Hess PR et al. Selective deletion […]
Contributed by Paul R. Hess, Adam S. Buntzman, Sabrina L. Murray, Ellen F. Young, and Jeffrey A. Frelinger;North Carolina State University College of Veterinary Medicine, Raleigh, NC;and University of North Carolina-Chapel Hill School of Medicine, Chapel Hill, NC CD8+ T cells constitute important effectors of the adaptive immune response, functioning principally to remove infected cells
Anderberg C, Li H, Fredriksson L, Andrae J, Betsholtz C, Li X, Eriksson U, Pietras K (2009) Paracrine signaling by platelet-derived growth factor-CC promotes tumor growth by recruitment of cancer-associated fibroblasts. Cancer Res 69(1):369-378. doi: 10.1158/0008-5472.CAN-08-2724 PMID: 19118022 Usage: Receptor stimulation and immunoprecipitation. B16/mock, B16/PDGF-C, and porcine aortic endothelial cells stably expressing PDGFR-a (a-PAE) were
Read the 2008 Newsletters and recent scientific references 2008, issue 1: Role of medial septal GABAergic neurons in learning and extinction: Effects of the novel GABA immunotoxin GAT1-SAP / by Pang KCH, Jiao X, Servatius RJ / featuring GAT1-SAP (Cat. #IT-32) SFN Poster of the Year Targeting Talk: Secondary Conjugate Protocol, Reducing Agents Targeting Tools:
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Loyd DR, Wang X, Murphy AZ (2008) Sex differences in micro-opioid receptor expression in the rat midbrain periaqueductal gray are essential for eliciting sex differences in morphine analgesia. J Neurosci 28:14007-14017. doi: 10.1523/JNEUROSCI.4123-08.2008 Summary: The authors test whether the periaqueductal gray (PAG), that contains a dense population of µ-opioid receptor (MOR)-expressing neurons, is sexually dimorphic.
Burk JA, Lowder MW, Altemose KE (2008) Attentional demands for demonstrating deficits following intrabasalis infusions of 192 IgG-saporin. Behav Brain Res 195:231-238. doi: 10.1016/j.bbr.2008.09.006 Summary: Attentional processing has been shown to be dependent on basal forebrain cholinergic inputs to the cerebral cortex. In this work the authors wished to specify which components should be used
Fitz NF, Gibbs RB, Johnson DA (2008) Selective lesion of septal cholinergic neurons in rats impairs acquisition of a delayed matching to position T-maze task by delaying the shift from a response to a place strategy. Brain Res Bull 77:356-360. doi: 10.1016/j.brainresbull.2008.08.016 Summary: It has been theorized that the effect of cholinergic lesions of the
Milstein JA, Dalley JW, Robbins TW (2010) Methylphenidate-induced impulsivity: pharmacological antagonism by beta-adrenoreceptor blockade. J Psychopharmacol 24:309-321. doi: 10.1177/0269881108098146 Summary: In this work bilateral 20 ng intracortical injections of anti-DBH-SAP (Cat. #IT-03) were used to examine the role of noradrenergic neurons in the control of psychostimulant-induced impulsivity. Although β-adrenoreceptor blockade abolished this impulsivity, lesioning noradrenergic
Zhang W, Gardell S, Zhang D, Xie JY, Agnes RS, Badghisi H, Hruby VJ, Rance N, Ossipov MH, Vanderah TW, Porreca F, Lai J (2009) Neuropathic pain is maintained by brainstem neurons co-expressing opioid and cholecystokinin receptors. Brain 132:778-787. doi: 10.1093/brain/awn330 Summary: It has been hypothesized that a subset of rostral ventromedial medulla (RVM) neurons
Wiley RG, Moore SA, Kline IV RH (2008) Analysis of inhibitory phase of formalin test: Effects of specific neural lesions. Neuroscience 2008 Abstracts 772.4/MM19. Society for Neuroscience, Washington, DC. Summary: The formalin test has been widely used as a model of persistent pain. The 90 mins of formalin-induced nocifensive responding can be divided into two
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