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  4. Selective lesion of septal cholinergic neurons in rats impairs acquisition of a delayed matching to position T-maze task by delaying the shift from a response to a place strategy.

Selective lesion of septal cholinergic neurons in rats impairs acquisition of a delayed matching to position T-maze task by delaying the shift from a response to a place strategy.

Fitz NF, Gibbs RB, Johnson DA (2008) Selective lesion of septal cholinergic neurons in rats impairs acquisition of a delayed matching to position T-maze task by delaying the shift from a response to a place strategy. Brain Res Bull 77:356-360. doi: 10.1016/j.brainresbull.2008.08.016

Summary: It has been theorized that the effect of cholinergic lesions of the medial septum on learning depend on the stressful nature of the task being learned. The authors injected 0.2 µg of 192-IgG-SAP (Cat. #IT-01) into the medial septum of rats then examined the strategies used by these animals to learn a delayed matching to position T-maze task. Lesioned animals were less able to switch from one strategy to another, indicating that this mechanism is the primary one affected by septal cholinergic lesions.

Related Products: 192-IgG-SAP (Cat. #IT-01)