Author name: Kristen Hartman

Neurotrophic factors rescue basal forebrain cholinergic neurons and improve performance on a spatial learning test.

Lee YS, Danandeh A, Baratta J, Lin CY, Yu J, Robertson RT (2013) Neurotrophic factors rescue basal forebrain cholinergic neurons and improve performance on a spatial learning test. Exp Neurol 249C:178-186. doi: 10.1016/j.expneurol.2013.08.012 Summary: It is thought that therapeutic treatments of the cholinergic system may be a viable treatment for Alzheimer’s disease. In order to […]

Neurotrophic factors rescue basal forebrain cholinergic neurons and improve performance on a spatial learning test. Read More »

Implication of cerebral dopamine-beta hydroxylase for cardiovascular and mood regulation in rats.

Chang ST, Liu YP, Huang CL, Wang PY, Tung CS (2013) Implication of cerebral dopamine-beta hydroxylase for cardiovascular and mood regulation in rats. Chin J Physiol 56(4):209-218. doi: 10.4077/CJP.2013.BAB103 Summary: The ascending fibers affected by norepinephrine are involved in a variety of processes, including emotion, anxiety, and regulation of central autonomic outflows such as cardiovascular

Implication of cerebral dopamine-beta hydroxylase for cardiovascular and mood regulation in rats. Read More »

Effects of intrathecal SNC80, a delta receptor ligand, on nociceptive threshold and dorsal horn substance p release.

Kouchek M, Takasusuki T, Terashima T, Yaksh TL, Xu Q (2013) Effects of intrathecal SNC80, a delta receptor ligand, on nociceptive threshold and dorsal horn substance p release. J Pharmacol Exp Ther 347(2):258-264. doi: 10.1124/jpet.113.206573 PMID: 23978562 Summary: In this work the authors utilized three different preclinical pain models to examine the effects of intrathecal

Effects of intrathecal SNC80, a delta receptor ligand, on nociceptive threshold and dorsal horn substance p release. Read More »

BB2 bombesin receptor-expressing spinal neurons transmit herpes-associated itch by BB2 receptor-independent signaling.

Sasaki A, Adhikari S, Andoh T, Kuraishi Y (2013) BB2 bombesin receptor-expressing spinal neurons transmit herpes-associated itch by BB2 receptor-independent signaling. Neuroreport 24(12):652-656. doi: 10.1097/WNR.0b013e32836352d8 Summary: Using a skin rash model created by inoculating mice with human herpes virus, bombesin receptor-expressing spinal neurons were lesioned intrathecally with 400 ng of Bombesin-SAP (Cat. #IT-40). Lesioned animals

BB2 bombesin receptor-expressing spinal neurons transmit herpes-associated itch by BB2 receptor-independent signaling. Read More »

Cortical metabolic deficits in a rat model of cholinergic basal forebrain degeneration.

Gelfo F, Petrosini L, Graziano A, De Bartolo P, Burello L, Vitale E, Polverino A, Iuliano A, Sorrentino G, Mandolesi L (2013) Cortical metabolic deficits in a rat model of cholinergic basal forebrain degeneration. Neurochem Res 38(10):2114-2123. doi: 10.1007/s11064-013-1120-2 Summary: In this work the authors investigated the connection between cholinergic depletion caused by conditions such

Cortical metabolic deficits in a rat model of cholinergic basal forebrain degeneration. Read More »

Saporin conjugated monoclonal antibody to the transcobalamin receptor TCblR/320 is effective in targeting and destroying cancer cells.

Quadros EV, Nakayama Y, Sequeira JM (2013) Saporin conjugated monoclonal antibody to the transcobalamin receptor TCblR/320 is effective in targeting and destroying cancer cells. J Cancer Ther 4(6):1074-1081. doi: 10.4236/jct.2013.46122 Summary: Although the transcobalamin receptor (TCb1R) is expressed in most cell types, the expression levels are increased in actively proliferating cells, and decreased in quiescent

Saporin conjugated monoclonal antibody to the transcobalamin receptor TCblR/320 is effective in targeting and destroying cancer cells. Read More »

Streptavidin-ZAP concentration

Q: Some suppliers sell their streptavidin conjugates in amounts given as streptavidin equivalents. Is that also the case for your product, Streptavidin-ZAP? What is important to me is to know what the molar concentration of streptavidin conjugate is, and the volume of your preparation. A: The molar concentration of Streptavidin-ZAP (Cat. #IT-27) will depend on

Streptavidin-ZAP concentration Read More »

Featured Article: Medial ganglionic eminence-like cells derived from human embryonic stem cells correct learning and memory deficits in an NGFr-lesioned mouse model

Liu Y, Weick JP, Liu H, Krencik R, Zhang X, Ma L, Zhou GM, Ayala M, Zhang S (2013) Featured Article: Medial ganglionic eminence-like cells derived from human embryonic stem cells correct learning and memory deficits in an NGFr-lesioned mouse model. Targeting Trends 14(3) Related Products: mu p75-SAP (Cat. #IT-16) Read the featured article in

Featured Article: Medial ganglionic eminence-like cells derived from human embryonic stem cells correct learning and memory deficits in an NGFr-lesioned mouse model Read More »

Targeting Article: Targeted Toxins, Optogenetics, and the BRAIN Initiative

News Article /

Contributed by Brian J. Russell The newly invigorated BRAIN initiative (Brain Research through Advancing Innovative Neurotechnologies, also known as the Brain Activity Map Project) has placed a premium on understanding the role of each neuron within the human brain. This effort has been our focus for some time via our Targeted Toxin technology. From the

Targeting Article: Targeted Toxins, Optogenetics, and the BRAIN Initiative Read More »

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