Sato M, Akasaka E, Saitoh I, Ohtsuka M, Nakamura S, Sakurai T, Watanabe S (2013) Targeted toxin-based selectable drug-free enrichment of Mammalian cells with high transgene expression. Biology (Basel) 2:341-355. doi: 10.3390/biology2010341 Summary: Cell transfection is a powerful tool for evaluation of function and expression of newly discovered genes as well as for both small […]
Koch H, Zanella S, Elsen GE, Smith L, Doi A, Garcia AJr, Wei AD, Xun R, Kirsch S, Gomez CM, Hevner RF, Ramirez JM (2013) Stable respiratory activity requires both P/Q-type and N-type voltage-gated calcium channels. J Neurosci 33(8):3633-3645. doi: 10.1523/JNEUROSCI.6390-11.2013 PMID: 23426690 Summary: Pharmacological experiments have suggested that sighs and normal respiration are highly
Gritton HJ, Stasiak AM, Sarter M, Lee TM (2013) Cognitive performance as a zeitgeber: cognitive oscillators and cholinergic modulation of the SCN entrain circadian rhythms. PLoS One 8(2):e56206. doi: 10.1371/journal.pone.0056206 PMID: 23441168 Objective: To examine how attention-demanding task performance interacts with circadian mechanisms in the SCN. Summary: The authors used site-specific injections of the 192
Rust S, Guillard S, Sachsenmeier K, Hay C, Davidson M, Karlsson A, Karlsson R, Brand E, Lowne D, Elvin J, Flynn M, Kurosawa G, Hollingsworth R, Jermutus L, Minter R (2013) Combining phenotypic and proteomic approaches to identify membrane targets in a ‘triple negative’ breast cancer cell type. Mol Cancer 12:11. doi: 10.1186/1476-4598-12-11 Summary: The
Li Q, Syrovets T, Simmet T, Ding J, Xu J, Chen W, Zhu D, Gao P (2013) Plasmin induces intercellular adhesion molecule 1 expression in human endothelial cells via nuclear factor-κB/mitogen-activated protein kinases-dependent pathways. Exp Biol Med (Maywood) 238(2):176-186. doi: 10.1177/1535370212473700 Summary: Intracellular adhesion molecule 1 (ICAM-1) mediates inflammatory cell migration – an early step
Zheng H, Rinaman L (2013) Yohimbine anxiogenesis in the elevated plus maze requires hindbrain noradrenergic neurons that target the anterior ventrolateral bed nucleus of the stria terminalis. Eur J Neurosci 37(8):1340-1349. doi: 10.1111/ejn.12123 Summary: The anterior ventrolateral bed nucleus of the stria terminalis (vIBST) appears to be important for increased noradrenergic signaling to trigger anxiety-like
Ren C, Luan L, Wui-Man Lau B, Huang X, Yang J, Zhou Y, Wu X, Gao J, Pickard GE, So KF, Pu M (2013) Direct retino-raphe projection alters serotonergic tone and affective behavior. Neuropsychopharmacology 38(7):1163-1175. doi: 10.1038/npp.2013.35 Summary: Although recent work has shown that some intrinsically photosensitive retinal ganglion cells (ipRGCs) are responsible for processing
Direct retino-raphe projection alters serotonergic tone and affective behavior. Read More »
Brayda-Bruno L, Mons N, Yee BK, Micheau J, Abrous DN, Nogues X, Marighetto A (2013) Partial loss in septo-hippocampal cholinergic neurons alters memory-dependent measures of brain connectivity without overt memory deficits. Neurobiol Dis 54:372-381. doi: 10.1016/j.nbd.2013.01.010 Summary: The authors examined whether partial degeneration of septo-hippocampal neurons alters brain activity patterns even without overt memory loss.
Torres Demichelis V, Vilcaes AA, Iglesias-Bartolome R, Ruggiero FM, Daniotti JL (2013) Targeted delivery of immunotoxin by antibody to ganglioside GD3: A novel drug delivery route for tumor cells. PLoS One 8(1):e55304. doi: 10.1371/journal.pone.0055304 Summary: The authors used the mouse monoclonal antibody R24 against ganglioside G3 with Mab-ZAP (Cat. #IT-04) to test the viability of
Szigeti C, Bencsik N, Simonka AJ, Legradi A, Kasa P, Gulya K (2013) Long-term effects of selective immunolesions of cholinergic neurons of the nucleus basalis magnocellularis on the ascending cholinergic pathways in the rat: A model for Alzheimer’s disease. Brain Res Bull 94C:9-16. doi: 10.1016/j.brainresbull.2013.01.007 Summary: 192-IgG-SAP (Cat. #IT-01) has been used extensively to generate