Author name: Kristen Hartman

Neurotrophin receptor p75 mediates the uptake of the amyloid beta (Abeta) peptide, guiding it to lysosomes for degradation in basal forebrain cholinergic neurons.

Ovsepian SV, Antyborzec I, O’Leary VB, Zaborszky L, Herms J, Oliver Dolly J (2013) Neurotrophin receptor p75 mediates the uptake of the amyloid beta (Abeta) peptide, guiding it to lysosomes for degradation in basal forebrain cholinergic neurons. Brain Struct Funct 219(5):1527-1541. doi: 10.1007/s00429-013-0583-x PMID: 23716278 Summary: Accumulation of β-amyloid in the brain is considered one […]

Neurotrophin receptor p75 mediates the uptake of the amyloid beta (Abeta) peptide, guiding it to lysosomes for degradation in basal forebrain cholinergic neurons. Read More »

The cells and circuitry for itch responses in mice.

Mishra SK, Hoon MA (2013) The cells and circuitry for itch responses in mice. Science 340(6135):968-971. doi: 10.1126/science.1233765 Summary: Although previous work implicated neurons expressing the GRP (gastrin-releasing peptide) receptor were in the pruritic, or itch pathway, transgenic mice lacking natriuretic polypeptide b (Nppb) were almost completely insensitive to itch. Using the custom conjugate Nppb-SAP

The cells and circuitry for itch responses in mice. Read More »

Cholinergic basal forebrain structures are involved in the mediation of the arousal effect of noradrenaline.

Lelkes Z, Porkka-Heiskanen T, Stenberg D (2013) Cholinergic basal forebrain structures are involved in the mediation of the arousal effect of noradrenaline. J Sleep Res 22(6):721-726. doi: 10.1111/jsr.12061 Summary: Wakefulness is enhanced by the injection of noradrenaline into the basal forebrain, but it has not been clear whether cholinergic or non-cholinergic neurons are involved. 230

Cholinergic basal forebrain structures are involved in the mediation of the arousal effect of noradrenaline. Read More »

Collagen-like cell-penetrating peptides

Yamazaki CM, Nakase I, Endo H, Kishimoto S, Mashiyama Y, Masuda R, Futaki S, Koide T (2013) Collagen-like cell-penetrating peptides. Angew Chem Int Ed Engl 52(21):5497-5500. doi: 10.1002/anie.201301266 Objective: To overcome drawbacks of cell-penetrating peptide (CPP)-conjugated forms, namely instability against attack by proteases, and binding to serum proteins that lowers the availability of the CPP

Collagen-like cell-penetrating peptides Read More »

State-dependent contribution of the hyperpolarization-activated na+/k+ and persistent na+ currents to respiratory rhythmogenesis in vivo.

Montandon G, Horner RL (2013) State-dependent contribution of the hyperpolarization-activated na+/k+ and persistent na+ currents to respiratory rhythmogenesis in vivo. J Neurosci 33(20):8716-8728. doi: 10.1523/JNEUROSCI.5066-12.2013 PMID: 23678115 Summary: The hyperpolarization-activated cation current in the preBötzinger complex (preBötC) was identified as a critical component of respiratory rhythm. An anti-neurokinin 1 receptor antibody (Cat. #AB-N04 replaced by

State-dependent contribution of the hyperpolarization-activated na+/k+ and persistent na+ currents to respiratory rhythmogenesis in vivo. Read More »

Photochemical internalization of CD133-targeting immunotoxins efficiently depletes sarcoma cells with stem-like properties and reduces tumorigenicity.

Stratford EW, Bostad M, Castro R, Skarpen E, Berg K, Hogset A, Myklebost O, Selbo PK (2013) Photochemical internalization of CD133-targeting immunotoxins efficiently depletes sarcoma cells with stem-like properties and reduces tumorigenicity. Biochim Biophys Acta 1830(8):4235-4243. doi: 10.1016/j.bbagen.2013.04.033 Summary: In this work the authors used photochemical internalization (PCI) to facilitate local cytosolic toxin release from

Photochemical internalization of CD133-targeting immunotoxins efficiently depletes sarcoma cells with stem-like properties and reduces tumorigenicity. Read More »

Cutting Edge: memory regulatory t cells require IL-7 and not IL-2 for their maintenance in peripheral tissues.

Gratz IK, Truong HA, Yang SH, Maurano MM, Lee K, Abbas AK, Rosenblum MD (2013) Cutting Edge: memory regulatory t cells require IL-7 and not IL-2 for their maintenance in peripheral tissues. J Immunol 190(9):4483-4487. doi: 10.4049/jimmunol.1300212 Summary: Recently a new class of regulatory T cells (mTregs) were found that persist in non-lymphoid tissues and

Cutting Edge: memory regulatory t cells require IL-7 and not IL-2 for their maintenance in peripheral tissues. Read More »

GABAergic neurons in the medial septum-diagonal band of Broca (MSDB) are important for acquisition of the classically conditioned eyeblink response.

Roland J, Janke K, Servatius R, Pang K (2014) GABAergic neurons in the medial septum-diagonal band of Broca (MSDB) are important for acquisition of the classically conditioned eyeblink response. Brain Struct Funct 219:1231-1237. doi: 10.1007/s00429-013-0560-4 Summary: The medial septum and vertical limb of the diagonal band of Broca (MSDB) are both important for learning and

GABAergic neurons in the medial septum-diagonal band of Broca (MSDB) are important for acquisition of the classically conditioned eyeblink response. Read More »

Striatal patch compartment lesions alter methamphetamine-induced behavior and immediate early gene expression in the striatum, substantia nigra and frontal cortex

Murray RC, Gilbert YE, Logan AS, Hebbard JC, Horner KA (2014) Striatal patch compartment lesions alter methamphetamine-induced behavior and immediate early gene expression in the striatum, substantia nigra and frontal cortex. Brain Struct Funct 219:1213-1229. doi: 10.1007/s00429-013-0559-x Summary: In this work, the authors investigated the function of the patch compartment in abnormally repetitive motor actions

Striatal patch compartment lesions alter methamphetamine-induced behavior and immediate early gene expression in the striatum, substantia nigra and frontal cortex Read More »

Epitopes of the highly immunogenic trichomonas vaginalis alpha-actinin are serodiagnostic targets for both women and men.

Neace CJ, Alderete JF (2013) Epitopes of the highly immunogenic trichomonas vaginalis alpha-actinin are serodiagnostic targets for both women and men. J Clin Microbiol 51(8):2483-2490. doi: 10.1128/JCM.00582-13 PMID: 23616456 Summary: Trichomonas vaginalis is an anaerobic protozoan that is the most common nonviral causative agent for sexually-transmitted infections. The presence of T. vaginalis in men is

Epitopes of the highly immunogenic trichomonas vaginalis alpha-actinin are serodiagnostic targets for both women and men. Read More »

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