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  4. GABAergic neurons in the medial septum-diagonal band of Broca (MSDB) are important for acquisition of the classically conditioned eyeblink response.

GABAergic neurons in the medial septum-diagonal band of Broca (MSDB) are important for acquisition of the classically conditioned eyeblink response.

Roland J, Janke K, Servatius R, Pang K (2014) GABAergic neurons in the medial septum-diagonal band of Broca (MSDB) are important for acquisition of the classically conditioned eyeblink response. Brain Struct Funct 219:1231-1237. doi: 10.1007/s00429-013-0560-4

Summary: The medial septum and vertical limb of the diagonal band of Broca (MSDB) are both important for learning and memory. There are strong connections between these two areas, and damage to one or the other can result in differing dysfunctions. The authors investigated how damage to GABAergic neurons in the MSDB affect acquisition of delay classical conditioning of the eyeblink response (CCER). Rats received 162 ng of GAT-1-SAP (Cat. #IT-32) into the medial septum and 130 ng of GAT-1-SAP into each diagonal band. Treated animals displayed impaired initial acquisition of the eyeblink response, indicating that MSDB GABAergic neurons modulate delay CCER – a task that is not dependent on the hippocampus.

Related Products: GAT1-SAP (Cat. #IT-32)