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Cholinergic basal forebrain structures are involved in the mediation of the arousal effect of noradrenaline.

Lelkes Z, Porkka-Heiskanen T, Stenberg D (2013) Cholinergic basal forebrain structures are involved in the mediation of the arousal effect of noradrenaline. J Sleep Res 22(6):721-726. doi: 10.1111/jsr.12061

Summary: Wakefulness is enhanced by the injection of noradrenaline into the basal forebrain, but it has not been clear whether cholinergic or non-cholinergic neurons are involved. 230 ng of 192-IgG-SAP (Cat. #IT-01) was administered to the horizontal diagonal band/substantia innominata/ magnocellular preoptic nucleus of rats. Upon treatment with methoxamine, lesioned animals lost the non-REM sleep-suppressing effect, but the REM sleep-suppressing effect remained intact.

Related Products: 192-IgG-SAP (Cat. #IT-01)