Saporin-S6: a useful tool in cancer therapy
Saporin-S6: a useful tool in cancer therapy Read More »
Flow cytometry for AB-N07
Q: We have a publication in review and put this statement in the paper, “The mouse monoclonal antibody to the low affinity nerve growth factor receptor (p75NTR; Advanced Targeting Systems) was derived from immunization of mice with WM245 melanoma cells and recognizes p75NTR in human, primate, rabbit, sheep, dog, cat, and pig. According to the
Flow cytometry for AB-N07 Read More »
Reprint: Selective immunotoxic lesions of basal forebrain cholinergic cells: Effects on learning and memory in rats.
Baxter MG, Bucci DJ, Gorman LK, Wiley RG, Gallagher M (2013) Reprint: Selective immunotoxic lesions of basal forebrain cholinergic cells: Effects on learning and memory in rats. Behav Neurosci 127(5):619-627 . doi: 10.1037/a0033939 Summary: In this reprint of a 1995 article, 192-IgG-SAP (Cat. #IT-01) was used to separate the depletion of cortical cholineacetyltransferase and behavioral
Selective immunotoxic lesions of basal forebrain cholinergic neurons: twenty years of research and new directions.
Baxter MG, Bucci DJ (2013) Selective immunotoxic lesions of basal forebrain cholinergic neurons: twenty years of research and new directions. Behav Neurosci 127(5):611-618 . doi: 10.1037/a0033781 Summary: This review covers twenty years of basal forebrain cholinergic lesioning. The initial use of 192-IgG-SAP (Cat. #IT-01) is discussed, as well as other immunotoxins such as GAT-1-SAP (Cat.
Featured Article: Role of spinal microglia in the development of morphine-induced hyperalgesia
Ferrini F, De Koninck Y (2013) Featured Article: Role of spinal microglia in the development of morphine-induced hyperalgesia. Targeting Trends 14(4) Related Products: Mac-1-SAP rat (Cat. #IT-33), Saporin (Cat. #PR-01) Read the featured article in Targeting Trends. See Also: Ferrini F et al. Morphine hyperalgesia gated through microglia-mediated disruption of neuronal Cl(-) homeostasis. Nat Neurosci
Cover Article: Role of spinal microglia in the development of morphine-induced hyperalgesia
Contributed by Francesco Ferrini (1) and Yves De Koninck (2,3) 1) Department of Veterinary Sciences, University of Turin,10095 Grugliasco, Turin, Italy 2) Institut universitaire en santé mentale de Québec, QC, G1J 2G3, Canada 3) Department of Psychiatry and Neuroscience, Université Laval, Québec, QC, G13 7P4, Canada Morphine-induced hyperalgesia and tolerance dramatically limit the use of
Hindbrain catecholamine neurons control rapid switching of metabolic substrate use during glucoprivation in male rats.
Li AJ, Wang Q, Dinh TT, Wiater MF, Eskelsen AK, Ritter S (2013) Hindbrain catecholamine neurons control rapid switching of metabolic substrate use during glucoprivation in male rats. Endocrinology 154(12):4570-4579. doi: 10.1210/en.2013-1589 Summary: Previous work has shown that corticosterone secretion in response to glucoprivation is at least in part controlled by hindbrain catecholamine neurons in
Oscillatory coupling within neonatal prefrontal-hippocampal networks is independent of selective removal of GABAergic neurons in the hippocampus.
Bitzenhofer SH, Hanganu-Opatz IL (2014) Oscillatory coupling within neonatal prefrontal-hippocampal networks is independent of selective removal of GABAergic neurons in the hippocampus. Neuropharmacology 77:57-67. doi: 10.1016/j.neuropharm.2013.09.007 PMID: 24056266 Summary: During cognitive tasks neuronal networks are entrained by oscillatory electrical rhythms with different frequencies. It has been proposed that GABAergic neurons in the prefrontal-hippocampal networks control
Noggin and Sonic hedgehog are involved in compensatory changes within the motoneuron-depleted mouse spinal cord.
Gulino R, Gulisano M (2013) Noggin and Sonic hedgehog are involved in compensatory changes within the motoneuron-depleted mouse spinal cord. J Neurol Sci 332(1-2):102-109. doi: 10.1016/j.jns.2013.06.029 Summary: Noggin (NOG) and Sonic hedgehog (Shh) are both involved in the generation and organization of neural tissues. In order to clarify the role of these two proteins in
A1 noradrenergic neurons lesions reduce natriuresis and hypertensive responses to hypernatremia in rats.
da Silva EF, Freiria-Oliveira AH, Custodio CH, Ghedini PC, Bataus LA, Colombari E, de Castro CH, Colugnati DB, Rosa DA, Cravo SL, Pedrino GR (2013) A1 noradrenergic neurons lesions reduce natriuresis and hypertensive responses to hypernatremia in rats. PLoS One 8(9):e73187. doi: 10.1371/journal.pone.0073187 Summary: Using bilateral 63-ng injections of Anti-DBH-SAP (Cat. #IT-03) into two levels