Author name: Kristen Hartman

Photochemical internalization of CD133-targeting immunotoxins efficiently depletes sarcoma cells with stem-like properties and reduces tumorigenicity.

Stratford EW, Bostad M, Castro R, Skarpen E, Berg K, Hogset A, Myklebost O, Selbo PK (2013) Photochemical internalization of CD133-targeting immunotoxins efficiently depletes sarcoma cells with stem-like properties and reduces tumorigenicity. Biochim Biophys Acta 1830(8):4235-4243. doi: 10.1016/j.bbagen.2013.04.033 Summary: In this work the authors used photochemical internalization (PCI) to facilitate local cytosolic toxin release from […]

Photochemical internalization of CD133-targeting immunotoxins efficiently depletes sarcoma cells with stem-like properties and reduces tumorigenicity. Read More »

Cutting Edge: memory regulatory t cells require IL-7 and not IL-2 for their maintenance in peripheral tissues.

Gratz IK, Truong HA, Yang SH, Maurano MM, Lee K, Abbas AK, Rosenblum MD (2013) Cutting Edge: memory regulatory t cells require IL-7 and not IL-2 for their maintenance in peripheral tissues. J Immunol 190(9):4483-4487. doi: 10.4049/jimmunol.1300212 Summary: Recently a new class of regulatory T cells (mTregs) were found that persist in non-lymphoid tissues and

Cutting Edge: memory regulatory t cells require IL-7 and not IL-2 for their maintenance in peripheral tissues. Read More »

GABAergic neurons in the medial septum-diagonal band of Broca (MSDB) are important for acquisition of the classically conditioned eyeblink response.

Roland J, Janke K, Servatius R, Pang K (2014) GABAergic neurons in the medial septum-diagonal band of Broca (MSDB) are important for acquisition of the classically conditioned eyeblink response. Brain Struct Funct 219:1231-1237. doi: 10.1007/s00429-013-0560-4 Summary: The medial septum and vertical limb of the diagonal band of Broca (MSDB) are both important for learning and

GABAergic neurons in the medial septum-diagonal band of Broca (MSDB) are important for acquisition of the classically conditioned eyeblink response. Read More »

Striatal patch compartment lesions alter methamphetamine-induced behavior and immediate early gene expression in the striatum, substantia nigra and frontal cortex

Murray RC, Gilbert YE, Logan AS, Hebbard JC, Horner KA (2014) Striatal patch compartment lesions alter methamphetamine-induced behavior and immediate early gene expression in the striatum, substantia nigra and frontal cortex. Brain Struct Funct 219:1213-1229. doi: 10.1007/s00429-013-0559-x Summary: In this work, the authors investigated the function of the patch compartment in abnormally repetitive motor actions

Striatal patch compartment lesions alter methamphetamine-induced behavior and immediate early gene expression in the striatum, substantia nigra and frontal cortex Read More »

Epitopes of the highly immunogenic trichomonas vaginalis alpha-actinin are serodiagnostic targets for both women and men.

Neace CJ, Alderete JF (2013) Epitopes of the highly immunogenic trichomonas vaginalis alpha-actinin are serodiagnostic targets for both women and men. J Clin Microbiol 51(8):2483-2490. doi: 10.1128/JCM.00582-13 PMID: 23616456 Summary: Trichomonas vaginalis is an anaerobic protozoan that is the most common nonviral causative agent for sexually-transmitted infections. The presence of T. vaginalis in men is

Epitopes of the highly immunogenic trichomonas vaginalis alpha-actinin are serodiagnostic targets for both women and men. Read More »

Medial ganglionic eminence-like cells derived from human embryonic stem cells correct learning and memory deficits.

Liu Y, Weick JP, Liu H, Krencik R, Zhang X, Ma L, Zhou GM, Ayala M, Zhang SC (2013) Medial ganglionic eminence-like cells derived from human embryonic stem cells correct learning and memory deficits. Nat Biotechnol 31(5):440-447. doi: 10.1038/nbt.2565 Summary: Progenitor cells were transplanted into mice that had received 1.5 μg of mu p75-SAP (Cat.

Medial ganglionic eminence-like cells derived from human embryonic stem cells correct learning and memory deficits. Read More »

Evaluating the role of neuronal nitric oxide synthase-containing striatal interneurons in methamphetamine-induced dopamine neurotoxicity.

Fricks-Gleason AN, Keefe KA (2013) Evaluating the role of neuronal nitric oxide synthase-containing striatal interneurons in methamphetamine-induced dopamine neurotoxicity. Neurotox Res 24(2):288-297. doi: 10.1007/s12640-013-9391-6 Summary: Using the fact that neuronal nitric oxide synthase (nNOS)-containing neurons in the striatum express the substance P receptor, the authors injected four locations in the striatum with 3 ng each

Evaluating the role of neuronal nitric oxide synthase-containing striatal interneurons in methamphetamine-induced dopamine neurotoxicity. Read More »

Cortical cholinergic input is required for normal auditory perception and experience-dependent plasticity in adult ferrets.

Leach ND, Nodal FR, Cordery PM, King AJ, Bajo VM (2013) Cortical cholinergic input is required for normal auditory perception and experience-dependent plasticity in adult ferrets. J Neurosci 33(15):6659-6671. doi: 10.1523/JNEUROSCI.5039-12.2013 Summary: In order to study how cholinergic input from the nucleus basalis affects auditory perception and learning, the authors injected a total of 35.2

Cortical cholinergic input is required for normal auditory perception and experience-dependent plasticity in adult ferrets. Read More »

Targeting Tools: FabFc-ZAP – A new secondary conjugate

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Background of General Preparation and Components: Over the last few years, riding on the coattails of the established customer base for the ZAP line of secondary conjugates, Fab-ZAP has become the most popular ATS product group in the catalog. Combining species-specific monovalent secondary antibodies with the cytotoxic ribosome-inactivating protein, Saporin, the Fab-ZAP line of products

Targeting Tools: FabFc-ZAP – A new secondary conjugate Read More »

Saporin Cleavage

Can you comment on the mechanism by which the SAP toxin is cleaved off from the antibody? Your website indicates that the cleavage occurs in the endosome. I just want to verify that it is not cleaved in the lysosome. From what we have gathered, there is a great probability that something gets broken in

Saporin Cleavage Read More »

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