Author name: Kristen Hartman

A novel model for evaluating therapies targeting human tumor vasculature and human cancer stem-like cells.

Burgos-Ojeda D, McLean K, Bai S, Pulaski H, Gong Y, Silva I, Skorecki K, Tzukerman M, Buckanovich RJ (2013) A novel model for evaluating therapies targeting human tumor vasculature and human cancer stem-like cells. Cancer Res 73(12):3555-3565. doi: 10.1158/0008-5472.CAN-12-2845 Objective: To evaluate tumor vascular markers (TVM) expression in a human embryonic stem cell–derived teratoma (hESCT) […]

A novel model for evaluating therapies targeting human tumor vasculature and human cancer stem-like cells. Read More »

Time course study of targeted ablation of KNDy neurons, but not tyrosine-hydroxylase neurons, in the rat arcuate nucleus using a neurokinin b-saporin.

Helena CV, Kalil B, Anselmo-Franci JA, Bertram R (2013) Time course study of targeted ablation of KNDy neurons, but not tyrosine-hydroxylase neurons, in the rat arcuate nucleus using a neurokinin b-saporin. Endocr Rev 34:OR47-5. 95th Annual Meetin and Expo, San Francisco. doi: 10.1093/edrv/34.supp.1 Summary: Ovariectomized rats were given bilateral injections of NK3-SAP (Cat. #IT-63) into

Time course study of targeted ablation of KNDy neurons, but not tyrosine-hydroxylase neurons, in the rat arcuate nucleus using a neurokinin b-saporin. Read More »

P2Y1 receptors expressed by C1 neurons determine peripheral chemoreceptor modulation of breathing, sympathetic activity, and blood pressure.

Wenker IC, Sobrinho CR, Takakura AC, Mulkey DK, Moreira TS (2013) P2Y1 receptors expressed by C1 neurons determine peripheral chemoreceptor modulation of breathing, sympathetic activity, and blood pressure. Hypertension 62(2):263-273. doi: 10.1161/HYPERTENSIONAHA.113.01487 Summary: Peripheral chemoreceptor activation response is mediated by catecholaminergic C1 cells in the rostral ventrolateral medulla (RVLM). The authors investigated the molecular mechanisms

P2Y1 receptors expressed by C1 neurons determine peripheral chemoreceptor modulation of breathing, sympathetic activity, and blood pressure. Read More »

A small molecule angiotensin II type 2 receptor (AT₂R) antagonist produces analgesia in a rat model of neuropathic pain by inhibition of p38 mitogen-activated protein kinase (MAPK) and p44/p42 MAPK activation in the dorsal root ganglia

Smith MT, Woodruff TM, Wyse BD, Muralidharan A, Walther T (2013) A small molecule angiotensin II type 2 receptor (AT₂R) antagonist produces analgesia in a rat model of neuropathic pain by inhibition of p38 mitogen-activated protein kinase (MAPK) and p44/p42 MAPK activation in the dorsal root ganglia. Pain Med 14(10):1557-1568. doi: 10.1111/pme.12157 PMID: 23742186 Objective:

A small molecule angiotensin II type 2 receptor (AT₂R) antagonist produces analgesia in a rat model of neuropathic pain by inhibition of p38 mitogen-activated protein kinase (MAPK) and p44/p42 MAPK activation in the dorsal root ganglia Read More »

An environment-dependent modulation of cortical neural response by forebrain cholinergic neurons in awake rat.

Ariffin MZ, Chang LS, Koh HC, Low CM, Khanna S (2013) An environment-dependent modulation of cortical neural response by forebrain cholinergic neurons in awake rat. Brain Res 1513:72-84. doi: 10.1016/j.brainres.2013.03.046 Summary: Rats received 168 ng of 192-IgG-SAP (Cat. #IT-01) into the medial septum and induction of c-Fos expression in response to either familiar or novel

An environment-dependent modulation of cortical neural response by forebrain cholinergic neurons in awake rat. Read More »

Neurotrophin receptor p75 mediates the uptake of the amyloid beta (Abeta) peptide, guiding it to lysosomes for degradation in basal forebrain cholinergic neurons.

Ovsepian SV, Antyborzec I, O’Leary VB, Zaborszky L, Herms J, Oliver Dolly J (2013) Neurotrophin receptor p75 mediates the uptake of the amyloid beta (Abeta) peptide, guiding it to lysosomes for degradation in basal forebrain cholinergic neurons. Brain Struct Funct 219(5):1527-1541. doi: 10.1007/s00429-013-0583-x PMID: 23716278 Summary: Accumulation of β-amyloid in the brain is considered one

Neurotrophin receptor p75 mediates the uptake of the amyloid beta (Abeta) peptide, guiding it to lysosomes for degradation in basal forebrain cholinergic neurons. Read More »

The cells and circuitry for itch responses in mice.

Mishra SK, Hoon MA (2013) The cells and circuitry for itch responses in mice. Science 340(6135):968-971. doi: 10.1126/science.1233765 Summary: Although previous work implicated neurons expressing the GRP (gastrin-releasing peptide) receptor were in the pruritic, or itch pathway, transgenic mice lacking natriuretic polypeptide b (Nppb) were almost completely insensitive to itch. Using the custom conjugate Nppb-SAP

The cells and circuitry for itch responses in mice. Read More »

Cholinergic basal forebrain structures are involved in the mediation of the arousal effect of noradrenaline.

Lelkes Z, Porkka-Heiskanen T, Stenberg D (2013) Cholinergic basal forebrain structures are involved in the mediation of the arousal effect of noradrenaline. J Sleep Res 22(6):721-726. doi: 10.1111/jsr.12061 Summary: Wakefulness is enhanced by the injection of noradrenaline into the basal forebrain, but it has not been clear whether cholinergic or non-cholinergic neurons are involved. 230

Cholinergic basal forebrain structures are involved in the mediation of the arousal effect of noradrenaline. Read More »

Collagen-like cell-penetrating peptides

Yamazaki CM, Nakase I, Endo H, Kishimoto S, Mashiyama Y, Masuda R, Futaki S, Koide T (2013) Collagen-like cell-penetrating peptides. Angew Chem Int Ed Engl 52(21):5497-5500. doi: 10.1002/anie.201301266 Objective: To overcome drawbacks of cell-penetrating peptide (CPP)-conjugated forms, namely instability against attack by proteases, and binding to serum proteins that lowers the availability of the CPP

Collagen-like cell-penetrating peptides Read More »

State-dependent contribution of the hyperpolarization-activated na+/k+ and persistent na+ currents to respiratory rhythmogenesis in vivo.

Montandon G, Horner RL (2013) State-dependent contribution of the hyperpolarization-activated na+/k+ and persistent na+ currents to respiratory rhythmogenesis in vivo. J Neurosci 33(20):8716-8728. doi: 10.1523/JNEUROSCI.5066-12.2013 PMID: 23678115 Summary: The hyperpolarization-activated cation current in the preBötzinger complex (preBötC) was identified as a critical component of respiratory rhythm. An anti-neurokinin 1 receptor antibody (Cat. #AB-N04 replaced by

State-dependent contribution of the hyperpolarization-activated na+/k+ and persistent na+ currents to respiratory rhythmogenesis in vivo. Read More »

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