Author name: Kristen Hartman

Saporin conjugated monoclonal antibody to the transcobalamin receptor TCblR/320 is effective in targeting and destroying cancer cells.

Quadros EV, Nakayama Y, Sequeira JM (2013) Saporin conjugated monoclonal antibody to the transcobalamin receptor TCblR/320 is effective in targeting and destroying cancer cells. J Cancer Ther 4(6):1074-1081. doi: 10.4236/jct.2013.46122 Summary: Although the transcobalamin receptor (TCb1R) is expressed in most cell types, the expression levels are increased in actively proliferating cells, and decreased in quiescent […]

Saporin conjugated monoclonal antibody to the transcobalamin receptor TCblR/320 is effective in targeting and destroying cancer cells. Read More »

Streptavidin-ZAP concentration

Q: Some suppliers sell their streptavidin conjugates in amounts given as streptavidin equivalents. Is that also the case for your product, Streptavidin-ZAP? What is important to me is to know what the molar concentration of streptavidin conjugate is, and the volume of your preparation. A: The molar concentration of Streptavidin-ZAP (Cat. #IT-27) will depend on

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Featured Article: Medial ganglionic eminence-like cells derived from human embryonic stem cells correct learning and memory deficits in an NGFr-lesioned mouse model

Liu Y, Weick JP, Liu H, Krencik R, Zhang X, Ma L, Zhou GM, Ayala M, Zhang S (2013) Featured Article: Medial ganglionic eminence-like cells derived from human embryonic stem cells correct learning and memory deficits in an NGFr-lesioned mouse model. Targeting Trends 14(3) Related Products: mu p75-SAP (Cat. #IT-16) Read the featured article in

Featured Article: Medial ganglionic eminence-like cells derived from human embryonic stem cells correct learning and memory deficits in an NGFr-lesioned mouse model Read More »

Targeting Article: Targeted Toxins, Optogenetics, and the BRAIN Initiative

News Article /

Contributed by Brian J. Russell The newly invigorated BRAIN initiative (Brain Research through Advancing Innovative Neurotechnologies, also known as the Brain Activity Map Project) has placed a premium on understanding the role of each neuron within the human brain. This effort has been our focus for some time via our Targeted Toxin technology. From the

Targeting Article: Targeted Toxins, Optogenetics, and the BRAIN Initiative Read More »

Cover Article: Medial ganglionic eminence-like cells derived from human embryonic stem cells correct learning and memory deficits in an NGFr-lesioned mouse model

News Article /

Contributed by Liu Y, Weick JP, Liu H, Krencik R, Zhang X, Ma L, Zhou GM, Ayala M, Zhang SC. Waisman Center, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin, USA. and Human Anatomy and Histology, Fudan University Shanghai Medical School, Shanghai, China. Basal forebrain neurons including cholinergic neurons and GABA interneurons

Cover Article: Medial ganglionic eminence-like cells derived from human embryonic stem cells correct learning and memory deficits in an NGFr-lesioned mouse model Read More »

Angiotensin II’s role in sodium lactate-induced panic-like responses in rats with repeated urocortin 1 injections into the basolateral amygdala: amygdalar angiotensin receptors and panic

Johnson PL, Sajdyk TJ, Fitz SD, Hale MW, Lowry CA, Hay-Schmidt A, Shekhar A (2013) Angiotensin II’s role in sodium lactate-induced panic-like responses in rats with repeated urocortin 1 injections into the basolateral amygdala: amygdalar angiotensin receptors and panic. Prog Neuropsychopharmacol Biol Psychiatry 44:248-256. doi: 10.1016/j.pnpbp.2013.02.014 PMID: 23523745 Objective: To test the hypothesis that the

Angiotensin II’s role in sodium lactate-induced panic-like responses in rats with repeated urocortin 1 injections into the basolateral amygdala: amygdalar angiotensin receptors and panic Read More »

A robust method to derive functional neural crest cells from human pluripotent stem cells

Kreitzer FR, Salomonis N, Sheehan A, Huang M, Park JS, Spindler MJ, Lizarraga P, Weiss WA, So PL, Conklin BR (2013) A robust method to derive functional neural crest cells from human pluripotent stem cells. Am J Stem Cells 2(2):119-131. PMID: 23862100 Usage: Immunocytochemistry 1:200 Related Products: NGFr (ME20.4, p75) Mouse Monoclonal (Cat. #AB-N07)

A robust method to derive functional neural crest cells from human pluripotent stem cells Read More »

Photochemical internalization (PCI) of immunotoxins targeting CD133 is specific and highly potent at femtomolar levels in cells with cancer stem cell properties.

Bostad M, Berg K, Hogset A, Skarpen E, Stenmark H, Selbo PK (2013) Photochemical internalization (PCI) of immunotoxins targeting CD133 is specific and highly potent at femtomolar levels in cells with cancer stem cell properties. J Control Release 168(3):317-326. doi: 10.1016/j.jconrel.2013.03.023 Summary: Targeted therapies for cancer can be trapped in the lysosome and compartmentalized away

Photochemical internalization (PCI) of immunotoxins targeting CD133 is specific and highly potent at femtomolar levels in cells with cancer stem cell properties. Read More »

Immunologic and chemical targeting of the tight-junction protein Claudin-6 eliminates tumorigenic human pluripotent stem cells

Ben-David U, Nudel N, Benvenisty N (2013) Immunologic and chemical targeting of the tight-junction protein Claudin-6 eliminates tumorigenic human pluripotent stem cells. Nat Commun 4:1992. doi: 10.1038/ncomms2992 PMID: 23778593 Objective: To identify a pluripotent cell specific surface marker and develop strategies to selectively eliminate tumorigenic human pluripotent stem cells (hPSCs) from mixed cell populations. Summary:

Immunologic and chemical targeting of the tight-junction protein Claudin-6 eliminates tumorigenic human pluripotent stem cells Read More »

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