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  4. Effects of intrathecal SNC80, a delta receptor ligand, on nociceptive threshold and dorsal horn substance p release.

Effects of intrathecal SNC80, a delta receptor ligand, on nociceptive threshold and dorsal horn substance p release.

Kouchek M, Takasusuki T, Terashima T, Yaksh TL, Xu Q (2013) Effects of intrathecal SNC80, a delta receptor ligand, on nociceptive threshold and dorsal horn substance p release. J Pharmacol Exp Ther 347(2):258-264. doi: 10.1124/jpet.113.206573

Summary: In this work the authors utilized three different preclinical pain models to examine the effects of intrathecal administration of the DOR agonist SNC80. One strategy was to assess NK-1 receptor (NK1r) internalization using anti-NK1r (Cat. #AB-N33AP) in IHC at a 1:3000 dilution on cryosections. The data indicate that the transmitter release from small peptidergic afferents is an effect mediated by DOR in the spinal cord.

Related Products: NK-1 Receptor Rabbit Polyclonal, affinity-purified (Cat. #AB-N33AP)