Author name: Kristen Hartman

Analysis of the sequence preference of saporin by deep sequencing

Hauf S, Rotrattanadumrong R, Yokobayashi Y (2022) Analysis of the sequence preference of saporin by deep sequencing. ACS Chem Biol 17(9):2619-2630. doi: 10.1021/acschembio.3c00733 PMID: 35969718 Objective: To study sequence-specific depurination of oligo nucleotides caused by saporin. Summary: Data shows the sequence preference of saporin for different substrates and show that the GAGA motif is not […]

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Posttranslational S-nitrosylation modification regulates HMGB1 secretion and promotes its proinflammatory and neurodegenerative effects

Yang R, Gao Y, Li H, Huang W, Tu D, Yang M, Liu X, Hong JS, Gao HM (2022) Posttranslational S-nitrosylation modification regulates HMGB1 secretion and promotes its proinflammatory and neurodegenerative effects. Cell Rep 40(11):111330. doi: 10.1016/j.celrep.2022.111330 PMID: 36103834 Objective: To demonstrate that S-nitrosylation (SNO) is essential and sufficient for inflammation-elicited HMGB1 secretion. Summary: Results

Posttranslational S-nitrosylation modification regulates HMGB1 secretion and promotes its proinflammatory and neurodegenerative effects Read More »

pH-sensitive endosomolytic peptides in gene and drug delivery: Endosomal escape and current challenges

Ahmad A, Khan JM (2022) pH-sensitive endosomolytic peptides in gene and drug delivery: Endosomal escape and current challenges. Journal of Drug Delivery Science and Technology 76:103786. doi: 10.1016/j.jddst.2022.103786 Objective: To provide an overview on mechanism of endosomal escape of pH-sensitive endosomolytic peptides. Summary: Discussion topics: the many forms of anionic and cationic pH-sensitive endosomolytic peptides

pH-sensitive endosomolytic peptides in gene and drug delivery: Endosomal escape and current challenges Read More »

The basal forebrain volume reduction detected by MRI does not necessarily link with the cholinergic neuronal loss in the Alzheimer’s disease mouse model

Zhou XA, Ngiam G, Qian L, Sankorrakul K, Coulson EJ, Chuang KH (2022) The basal forebrain volume reduction detected by MRI does not necessarily link with the cholinergic neuronal loss in the Alzheimer’s disease mouse model. Neurobiol Aging 117:24-32. doi: 10.1016/j.neurobiolaging.2022.03.017 PMID: 35640461 Objective: Assess basal forebrain (BF) cholinergic neuron number by histological counts and

The basal forebrain volume reduction detected by MRI does not necessarily link with the cholinergic neuronal loss in the Alzheimer’s disease mouse model Read More »

Structure and biological properties of ribosome-inactivating proteins and lectins from elder (Sambucus nigra L.) leaves

Iglesias R, Russo R, Landi N, Valletta M, Chambery A, Di Maro A, Bolognesi A, Ferreras JM, Citores L (2022) Structure and biological properties of ribosome-inactivating proteins and lectins from elder (Sambucus nigra L.) leaves. Toxins 14(9):611. doi: 10.3390/toxins14090611 Summary: This work contributes to expanding our knowledge of the family of RIPs and RIP-related lectins

Structure and biological properties of ribosome-inactivating proteins and lectins from elder (Sambucus nigra L.) leaves Read More »

Laminarin attenuates ros-mediated cell migration and invasiveness through mitochondrial dysfunction in pancreatic cancer cells

Lee W, Song G, Bae H (2022) Laminarin attenuates ros-mediated cell migration and invasiveness through mitochondrial dysfunction in pancreatic cancer cells. Antioxidants (Basel) 11(9):1714. doi: 10.3390/antiox11091714 PMID: 36139787 Objective: To determine the effects of laminarin on pancreatic cancer. Summary: Laminarin showed synergistic effects when combined with 5-FU, a standard anticancer agent for pancreatic ductal adenocarcinoma

Laminarin attenuates ros-mediated cell migration and invasiveness through mitochondrial dysfunction in pancreatic cancer cells Read More »

Stimulation of the muscarinic receptor M4 activates quiescent neural precursor cells and ameliorates medial septum cholinergic lesion-induced impairments in adult hippocampal neurogenesis

Madrid LI, Bandhavkar S, Hafey K, Jimenez-Martin J, Milne M, Coulson EJ, Jhaveri DJ (2022) Stimulation of the muscarinic receptor M4 activates quiescent neural precursor cells and ameliorates medial septum cholinergic lesion-induced impairments in adult hippocampal neurogenesis. bioRxiv 2022.08.25.505357. doi: 10.1101/2022.08.25.505357 Objective: To investigate the contribution of basal forebrain medial septum (MS) and diagonal band

Stimulation of the muscarinic receptor M4 activates quiescent neural precursor cells and ameliorates medial septum cholinergic lesion-induced impairments in adult hippocampal neurogenesis Read More »

Prenatal exposure to valproic acid causes allodynia associated with spinal microglial activation

Imado E, Sun S, Abawa AR, Tahara T, Kochi T, Huynh TNB, Asano S, Hasebe S, Nakamura Y, Hisaoka-Nakashima K, Kotake Y, Irifune M, Tsuga K, Takuma K, Morioka N, Kiguchi N, Ago Y (2022) Prenatal exposure to valproic acid causes allodynia associated with spinal microglial activation. Neurochem Int 160:105415. doi: 10.1016/j.neuint.2022.105415 Objective: To further

Prenatal exposure to valproic acid causes allodynia associated with spinal microglial activation Read More »

From immunotoxins to suicide toxin delivery approaches: Is there a clinical opportunity? 

Ardini M, Vago R, Fabbrini MS, Ippoliti R (2022) From immunotoxins to suicide toxin delivery approaches: Is there a clinical opportunity?. Toxins (Basel) 14(9):579. doi: 10.3390/toxins14090579 PMID: 36136517 Objective: To give an overview describing some of the bacterial and plant enzymes studied so far for their delivery and controlled expression in tumor models. Summary: “Suicide

From immunotoxins to suicide toxin delivery approaches: Is there a clinical opportunity?  Read More »

From immunotoxins to suicide toxin delivery approaches: Is there a clinical opportunity?

Ardini M, Vago R, Fabbrini MS, Ippoliti R (2022) From immunotoxins to suicide toxin delivery approaches: Is there a clinical opportunity?. Toxins (Basel) 14(9):579. doi: 10.3390/toxins14090579 PMID: 36136517 Objective: To give an overview describing some of the bacterial and plant enzymes studied so far for their delivery and controlled expression in tumor models. Summary: “Suicide

From immunotoxins to suicide toxin delivery approaches: Is there a clinical opportunity? Read More »

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