Lecrux C, Sandoe C, Neupane S, Kropf P, Toussay X, Tong X, Lacalle-Aurioles M, Shmuel A, Hamel E (2017) Impact of altered cholinergic tones on the neurovascular coupling response to whisker stimulation. J Neurosci 37:1518-1531. doi: 10.1523/JNEUROSCI.1784-16.2016 Summary: The authors assessed the effects of varying ACh tone on whisker-evoked NVC responses in rat barrel cortex. […]
Lecrux et al. Impact of altered cholinergic tones on the neurovascular coupling response to whisker stimulation. Journal of Neuroscience (2017), 1784-16. PMID: 28069927 Brain imaging techniques that use vascular signals to map changes in neuronal activity rely on the coupling between electrophysiology and hemodynamics, a phenomenon referred to “neurovascular coupling” (NVC). It is unknown whether
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Jiao et al. Differentiation defect in neural crest-derived smooth muscle cells in patients with aortopathy associated with bicuspid aortic valves. EBioMedicine (2016) 10:282-90. PMID: 27394642 Individuals with bicuspid aortic valves (BAV) are at a higher risk of developing thoracic aortic aneurysms (TAA) than patients with trileaflet aortic valves (TAV). Aneurysms associated with BAV most commonly
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Contributed by Patrick Shramm, Product Manager for Fab-pHast We are pleased to announce a new set of tools to rapidly screen antibodies, Fab-pHast conjugates. The ATS pHAST product line provides the FASTEST results in quantitative testing of your antibody’s specific-binding and internalization. Fab-pHast contains a pH-dependent fluorescent reporter that increases intensity in acidic surroundings, such
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Contributed by S C Kelly, P T Nelson, S E Counts Alzheimer’s disease (AD) is a progressive neurodegenerative disorder that most commonly affects individuals over the age of 65. While of unknown etiology, AD is characterized by a steady decline in cognitive functions including memory, attention, executive functions, and language. There is currently no disease-modifying therapy
Wang D, Wang A, Wu F, Qiu X, Li Y, Chu J, Huang WC, Xu K, Gong X, Li S (2017) Sox10+ adult stem cells contribute to biomaterial encapsulation and microvascularization. Sci Rep 7:40295. doi: 10.1038/srep40295 PMID: 28071739 Objective: To show that Sox10+ adult stem cells contribute to both encapsulation and microvessel formation. Summary: This
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As we start a new year, we at Advanced Targeting Systems are more dedicated than ever to providing our customers with the innovative, cutting-edge tools that will accelerate and optimize research. Scientists around the world have published exciting new data to advance our knowledge of how specific cell types affect behavior and disease. With each new discovery, possibilities
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Konig N, Trolle C, Kapuralin K, Adameyko I, Mitrecic D, Aldskogius H, Shortland PJ, Kozlova EN (2017) Murine neural crest stem cells and embryonic stem cell-derived neuron precursors survive and differentiate after transplantation in a model of dorsal root avulsion. J Tissue Eng Regen Med 11(1):129-137. doi: 10.1002/term.1893 PMID: 24753366 Objective: To compare survival and
Kelly SC, Nelson PT, Counts SE (2017) Featured Article: The locus coeruleus: a potential link between cerebrovascular and neuronal pathology in Alzheimer’s disease. Targeting Trends 18 Related Products: Anti-DBH-SAP (Cat. #IT-03), Mouse IgG-SAP (Cat. #IT-18) Read the featured article in Targeting Trends. See Also: Kelly SC et al. The locus coeruleus: a potential link between
Read the 2016 newsletters and recent scientific references 2016, issue 1: Striatal patch compartment lesions reduce cocaine-induced repetitive behaviors / by KA Horner and collaborators R Murray and MC Logan Mercer / featuring Dermorphin-SAP (Cat. #IT-12) From the President: New Beginnings Targeting Talk: Safety of the Toxin Featured Products: Custom Conjugates 2016, issue 2: Cerebral
Targeting Trends 2016 Newsletter Read More »