Author name: Kristen Hartman

Derivation of corneal keratocyte-like cells from human induced pluripotent stem cells.

Naylor R, McGhee C, Cowan C, Davidson A, Holm T, Sherwin T (2016) Derivation of corneal keratocyte-like cells from human induced pluripotent stem cells. PLoS One 11:e0165464. doi: 10.1371/journal.pone.0165464 PMID: 27792791 Summary: Slides containing cryosections were dried overnight at 4°C and then washed twice in Tris Buffered Saline containing 0.1% Triton X100 (TBST). Slides were […]

Derivation of corneal keratocyte-like cells from human induced pluripotent stem cells. Read More »

Differential roles for cortical versus sub-cortical noradrenaline and modulation of impulsivity in the rat.

Benn A, Robinson E (2017) Differential roles for cortical versus sub-cortical noradrenaline and modulation of impulsivity in the rat. Psychopharmacology (Berl) 234:255-266.. doi: 10.1007/s00213-016-4458-8 Summary: Atomoxetine is a noradrenaline re-uptake inhibitor licensed for the treatment of adult and childhood attention deficit hyperactivity disorder. Although atomoxetine has established efficacy, the mechanisms which mediate its effects are

Differential roles for cortical versus sub-cortical noradrenaline and modulation of impulsivity in the rat. Read More »

GABA-A receptor activity in the noradrenergic locus coeruleus drives trigeminal neuropathic pain in the rat; contribution of NAα1 receptors in the medial prefrontal cortex.

Kaushal R, Taylor B, Jamal A, Zhang L, Ma F, Donahue R, Westlund K (2016) GABA-A receptor activity in the noradrenergic locus coeruleus drives trigeminal neuropathic pain in the rat; contribution of NAα1 receptors in the medial prefrontal cortex. Neuroscience 334:148-159. doi: 10.1016/j.neuroscience.2016.08.005 Summary: The goal of this study was to investigate the role of

GABA-A receptor activity in the noradrenergic locus coeruleus drives trigeminal neuropathic pain in the rat; contribution of NAα1 receptors in the medial prefrontal cortex. Read More »

A2 noradrenergic neurons regulate forced swim test immobility.

Nam H, Kerman I (2016) A2 noradrenergic neurons regulate forced swim test immobility. Physiol Behav 165:339-349. doi: 10.1016/j.physbeh.2016.08.020 Summary: Wistar-Kyoto rats are often used as a model of depression, and exhibit high levels of immobility when subjected to a forced swim test (FST). Researchers discovered relative hyperactivation in the locus coeruleus of WKY rats compared

A2 noradrenergic neurons regulate forced swim test immobility. Read More »

Cell surface GRP78 as a biomarker and target for suppressing glioma cells

Kang BR, Yang SH, Chung BR, Kim W, Kim Y (2016) Cell surface GRP78 as a biomarker and target for suppressing glioma cells. Sci Rep 6:34922. doi: 10.1038/srep34922. PMID: 27713511 Summary: The publication discusses the identification of cell surface GRP78 as a promising biomarker for glioma, a type of brain tumor. Furthermore, it highlights the

Cell surface GRP78 as a biomarker and target for suppressing glioma cells Read More »

Featured Article: Targeted lesioning reveals role of nucleus incertus in the anxiogenic effect of buspirone

Kumar JR, Rajkumar R, Lee LC, Dawe GS (2016) Featured Article: Targeted lesioning reveals role of nucleus incertus in the anxiogenic effect of buspirone. Targeting Trends 17(4) Related Products: CRF-SAP (Cat. #IT-13) Read the featured article in Targeting Trends. See Also: Kumar J et al. Nucleus incertus contributes to an anxiogenic effect of buspirone in

Featured Article: Targeted lesioning reveals role of nucleus incertus in the anxiogenic effect of buspirone Read More »

Neuronal and glial changes in rat hippocampal formation after cholinergic deafferentation

Paban V, Valable S, Baril N, Gilbert V, Chambon C, & Alescio-Lautier B (2016) Neuronal and glial changes in rat hippocampal formation after cholinergic deafferentation. J Biomol Res Ther 5(3):1000147. doi: 10.4172/2167-7956.1000147 Summary: The effects of cholinergic insult were studied in the hippocampal formation of cholinergic lesioned rats at metabolic and cellular levels by in

Neuronal and glial changes in rat hippocampal formation after cholinergic deafferentation Read More »

Neuroprotective effects of testosterone metabolites and dependency on receptor action on the morphology of somatic motoneurons following the death of neighboring motoneurons.

Cai Y, Chew C, Muñoz F, Sengelaub D (2017) Neuroprotective effects of testosterone metabolites and dependency on receptor action on the morphology of somatic motoneurons following the death of neighboring motoneurons. Dev Neurobiol 77:691-707.. doi: 10.1002/dneu.22445 Summary: In this study the authors examined whether the protective effects of testosterone could be mediated via its androgenic

Neuroprotective effects of testosterone metabolites and dependency on receptor action on the morphology of somatic motoneurons following the death of neighboring motoneurons. Read More »

Cover Article: Targeted lesioning reveals role of nucleus incertus in the anxiogenic effect of buspirone

News Article /

By Jigna Rajesh Kumar, [a, b, c, d] Ramamoorthy Rajkumar, [a, b, c] Liying Corinne Lee, [a, b, c] Gavin S. Dawe [a, b, c, d][a] Dept Pharmacology, Yong Loo Lin School of Medicine, National University Health System, National University of Singapore, 117600, Singapore [b] Neurobiology and Ageing Programme, Life Sciences Institute, National University of

Cover Article: Targeted lesioning reveals role of nucleus incertus in the anxiogenic effect of buspirone Read More »

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