Author name: Kristen Hartman

Electrospun polycaprolactone/chitosan scaffolds for nerve tissue engineering: physicochemical characterization and Schwann cell biocompatibility

Bolaina-Lorenzo E, Martínez-Ramos C, Monleón-Pradas M, Herrera-Kao W, Cauich-Rodríguez JV, Cervantes-Uc JM (2016) Electrospun polycaprolactone/chitosan scaffolds for nerve tissue engineering: physicochemical characterization and Schwann cell biocompatibility. Biomed Mater 12(1):015008. doi: 10.1088/1748-605x/12/1/015008 PMID: 27934786 Objective: To study the effect of scaffold compositions on its physicochemical and biological properties. Summary: Immunochemistry analysis with p75 analysis confirmed that […]

Electrospun polycaprolactone/chitosan scaffolds for nerve tissue engineering: physicochemical characterization and Schwann cell biocompatibility Read More »

Cholinergic basal forebrain lesion decreases neurotrophin signaling without affecting tau hyperphosphorylation in genetically susceptible mice.

Turnbull M, Coulson E (2017) Cholinergic basal forebrain lesion decreases neurotrophin signaling without affecting tau hyperphosphorylation in genetically susceptible mice. J Alzheimers Dis 55:1141-1154.. doi: 10.3233/JAD-160805 Summary: Alzheimer’s disease(AD) is a progressive, irreversible neurodegenerative disease that destroys memory and cognitive function. Aggregates of hyperphosphorylated tau protein are a prominent feature in the brain of patients

Cholinergic basal forebrain lesion decreases neurotrophin signaling without affecting tau hyperphosphorylation in genetically susceptible mice. Read More »

Transcriptomic analysis of mouse cochlear supporting cell maturation reveals large-scale changes in notch responsiveness prior to the onset of hearing.

Maass J, Gu R, Cai T, Wan Y, Cantellano S, Asprer J, Zhang H, Jen H, Edlund R, Liu Z, Groves A (2016) Transcriptomic analysis of mouse cochlear supporting cell maturation reveals large-scale changes in notch responsiveness prior to the onset of hearing. PLoS One 11:e0167286. doi: 10.1371/journal.pone.0167286 PMID: 27918591 Summary: The ability of neonatal

Transcriptomic analysis of mouse cochlear supporting cell maturation reveals large-scale changes in notch responsiveness prior to the onset of hearing. Read More »

Identification of novel macropinocytosing human antibodies by phage display and high-content analysis.

Ha K, Bidlingmaier S, Su Y, Lee N, Liu B (2017) Identification of novel macropinocytosing human antibodies by phage display and high-content analysis. Methods Enzymol 585:91-110. doi: 10.1016/bs.mie.2016.10.004 Objective: To describe a method for identifying antibodies that internalize via macropinocytosis by screening phage-displayed single-chain antibody selection outputs with an automated fluorescent microscopy-based high-content analysis platform.

Identification of novel macropinocytosing human antibodies by phage display and high-content analysis. Read More »

Novel targets for modulation of plasticity in a mouse model of motoneuron degeneration.

Gulino R, Forte S, Parenti R, Gulisano M (2016) Novel targets for modulation of plasticity in a mouse model of motoneuron degeneration. Neuroscience 2016 Abstracts 812.14 / OO13. Society for Neuroscience, San Diego, CA. Summary: A successful spinal cord repairing strategy should involve the activation of neural precursor cells. Unfortunately, their ability to generate neurons

Novel targets for modulation of plasticity in a mouse model of motoneuron degeneration. Read More »

Effects of protein kinase C activation on attention deficits following loss of corticopetal cholinergic neurons.

Leong CS, Maness EB, Baraki DI, Burk JA (2016) Effects of protein kinase C activation on attention deficits following loss of corticopetal cholinergic neurons. Neuroscience 2016 Abstracts 833.03 / HHH22 . Society for Neuroscience, San Diego, CA. Summary: Alzheimer’s disease (AD) is a neurodegenerative dementia characterized by memory loss, cognitive impairment, and attention deficits. Damage

Effects of protein kinase C activation on attention deficits following loss of corticopetal cholinergic neurons. Read More »

Cholinergic-dependent shifts to cue-directed behavior.

Phillips KB, Sarter M (2016) Cholinergic-dependent shifts to cue-directed behavior. Neuroscience 2016 Abstracts 833.11 / HHH30. Society for Neuroscience, San Diego, CA. Summary: Successful cue detection requires cortical cholinergic signaling. Recent evidence has elucidated the role of phasic, short-timescale, regionally-specific cholinergic signals, termed “cholinergic transients”, in cue detection. Cholinergic transients in the right prefrontal cortex

Cholinergic-dependent shifts to cue-directed behavior. Read More »

Effects of N-desmethylclozapine on attentional performance following loss of basal forebrain corticopetal cholinergic inputs.

Maness EBL, Leong CS, Burk JA (2016) Effects of N-desmethylclozapine on attentional performance following loss of basal forebrain corticopetal cholinergic inputs. Neuroscience 2016 Abstracts 833.15 / HHH34. Society for Neuroscience, San Diego, CA. Summary: Corticopetal cholinergic neurons play a vital role in attentional processing, and dysregulation of this system contributes to central nervous system disorders

Effects of N-desmethylclozapine on attentional performance following loss of basal forebrain corticopetal cholinergic inputs. Read More »

Preventing falls in PD in a rat model of impaired cognitive control of complex movements by a pro-cholinergic combination treatment.

Kucinski AJ, De Jong IEM, Sarter M (2016) Preventing falls in PD in a rat model of impaired cognitive control of complex movements by a pro-cholinergic combination treatment. Neuroscience 2016 Abstracts 835.15 / III34. Society for Neuroscience, San Diego, CA. Summary: Parkinson’s disease (PD) patients, in addition to primary motor symptoms resulting from extensive losses

Preventing falls in PD in a rat model of impaired cognitive control of complex movements by a pro-cholinergic combination treatment. Read More »

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