Kumar J, Rajkumar R, Lee L, Dawe G (2016) Nucleus incertus contributes to an anxiogenic effect of buspirone in rats: Involvement of 5-HT1A receptors. Neuropharmacology 110:1-14. doi: 10.1016/j.neuropharm.2016.07.019 Summary: The nucleus incertus (NI) is involved in stress and anxiety responses. The NI is a cluster of GABAergic neurons in the brainstem, and coexpresses CRF, 5-HT1A […]
By Rahul Palchaudhuri, Ph.D., Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, Massachusetts, USA Hematopoietic stem cell transplantation (HSCT) has been clinically used for 58 years and offers life-saving therapies for a variety of malignant and non-malignant blood disorders. Currently 50,000 transplants are performed globally per year with 90% of these for the
Anti-OX1R-SAP (Cat. #BETA-007) eliminates mouse, rat, and guinea pig cells expressing the orexin 1 receptor. All other cells are left untouched. Anti-OX2R-SAP (Cat. #BETA-008) eliminates rat cells expressing the orexin 2 receptor (OX2R). All other cells are left untouched. These two immunotoxins are being offered as part of our Beta Testing program. They have not
Toolbox: Orexin Receptor Antibody Conjugates Read More »
ATS is pleased to re-release a product and kit specific for the Orexin 2 receptor (OX2R). The Orexin 1 and Orexin 2 receptors are found in the perifornical area/latero-posterior hypothalamus, and projections from this area cover much of the brain. These receptors have been implicated in various neurophysiological and neuropsychological disorders such as narcolepsy, insomnia,
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Wuzzup? No. What’s ZAP? Some of our products have SAP in the name, like 192-IgG-SAP (Cat. #IT-01). Some of our products have ZAP in the name, like Hum-ZAP (Cat. #IT-22). First, what’s the same about ZAP and SAP? They both mean Saporin. The payload that Advanced Targeting Systems made famous to specifically eliminate targeted cells.
From the President: What’s ZAP? Read More »
Lim J, Stafford B, Nguyen P, Lien B, Wang C, Zukor K, He Z, Huberman A (2016) Neural activity promotes long-distance, target-specific regeneration of adult retinal axons. Nat Neurosci 19:1073-1084. doi: 10.1038/nn.4340 PMID: 27399843 Summary: Axons in the CNS fail to regenerate after injury. Scientists sought to identify strategies that would allow retinal ganglion cell
Hay C, Sult E, Huang Q, Mulgrew K, Fuhrmann S, McGlinchey K, Hammond S, Rothstein R, Rios-Doria J, Poon E, Holoweckyj N, Durham N, Leow C, Diedrich G, Damschroder M, Herbst R, Hollingsworth R, Sachsenmeier K (2016) Targeting CD73 in the tumor microenvironment with MEDI9447. Oncoimmunology 5:e1208875. doi: 10.1080/2162402X.2016.1208875 Summary: MEDI9447 is a human monoclonal
Targeting CD73 in the tumor microenvironment with MEDI9447. Read More »
Gilabert-Oriol R, Thakur M, Haussmann K, Niesler N, Bhargava C, Görick C, Fuchs H, Weng A (2016) Saponins from Saponaria officinalis L. augment the efficacy of a Rituximab-immunotoxin. Planta Med 82:1525-1531. doi: 10.1055/s-0042-110495 Summary: It is known that triterpenoidal saponins that come from Saponaria officinalis, the plant that saporin comes from, increases the cytotoxicity of
Saponins from Saponaria officinalis L. augment the efficacy of a Rituximab-immunotoxin. Read More »
Q: I’ve been looking at your secondary conjugates and want to see if my targeting agent is specific to certain cells. Which secondary conjugate should I use? A: It depends on two factors: 1) the type of assay you want to use, and 2) the kind of targeting agent you want to use. For in
Which secondary ZAP conjugate should I use? Read More »