Kelly SC, Nelson PT, Counts SE (2016) The locus coeruleus: a potential link between cerebrovascular and neuronal pathology in Alzheimer’s disease. Neuroscience 2016 Abstracts 786.11 / H7. Society for Neuroscience, San Diego, CA. Summary: Noradrenergic locus coeruleus (LC) neuron loss is a major feature of Alzheimer’s disease (AD). The LC is the primary source of […]
Ruiz AD, Hays S, Berry A, Vallejo S, Barron L, Carrier X (2016) Enhanced motor recovery by vagus nerve stimulation requires cholinergic innervation in a rat model of ischemic stroke. Neuroscience 2016 Abstracts 807.20 / HH11. Society for Neuroscience, San Diego, CA. Summary: Stroke is a debilitating neurological insult that affects approximately 795,000 people in
Gulino R, Forte S, Parenti R, Gulisano M (2016) Novel targets for modulation of plasticity in a mouse model of motoneuron degeneration. Neuroscience 2016 Abstracts 812.14 / OO13. Society for Neuroscience, San Diego, CA. Summary: A successful spinal cord repairing strategy should involve the activation of neural precursor cells. Unfortunately, their ability to generate neurons
Novel targets for modulation of plasticity in a mouse model of motoneuron degeneration. Read More »
Leong CS, Maness EB, Baraki DI, Burk JA (2016) Effects of protein kinase C activation on attention deficits following loss of corticopetal cholinergic neurons. Neuroscience 2016 Abstracts 833.03 / HHH22 . Society for Neuroscience, San Diego, CA. Summary: Alzheimer’s disease (AD) is a neurodegenerative dementia characterized by memory loss, cognitive impairment, and attention deficits. Damage
Phillips KB, Sarter M (2016) Cholinergic-dependent shifts to cue-directed behavior. Neuroscience 2016 Abstracts 833.11 / HHH30. Society for Neuroscience, San Diego, CA. Summary: Successful cue detection requires cortical cholinergic signaling. Recent evidence has elucidated the role of phasic, short-timescale, regionally-specific cholinergic signals, termed “cholinergic transients”, in cue detection. Cholinergic transients in the right prefrontal cortex
Cholinergic-dependent shifts to cue-directed behavior. Read More »
Maness EBL, Leong CS, Burk JA (2016) Effects of N-desmethylclozapine on attentional performance following loss of basal forebrain corticopetal cholinergic inputs. Neuroscience 2016 Abstracts 833.15 / HHH34. Society for Neuroscience, San Diego, CA. Summary: Corticopetal cholinergic neurons play a vital role in attentional processing, and dysregulation of this system contributes to central nervous system disorders
Kucinski AJ, De Jong IEM, Sarter M (2016) Preventing falls in PD in a rat model of impaired cognitive control of complex movements by a pro-cholinergic combination treatment. Neuroscience 2016 Abstracts 835.15 / III34. Society for Neuroscience, San Diego, CA. Summary: Parkinson’s disease (PD) patients, in addition to primary motor symptoms resulting from extensive losses
Rajakumar R (2016) Developmental disturbances in thalamocortical connection are sufficient to produce almost all features of schizophrenia. Neuroscience 2016 Abstracts 845.01 / LLL41. Society for Neuroscience, San Diego, CA. Summary: Partial ablation of subplate of the developing frontal cortex was achieved by two different approaches in PD1 S-D rat pups: infusions of either P75 receptor
Wiley RG, Yezierski R, Vierck Jr CJ (2016) Cerebral cholinergic mechanisms in pain: CBF lesions vs systemic scopolamine. Neuroscience 2016 Abstracts 525.15 / SS2. Society for Neuroscience, San Diego, CA. Summary: Cholinergic inputs to the cerebral cortex and limbic system, originating primarily from the cholinergic basal forebrain (CBF), play an important role in cortical sensory
Cerebral cholinergic mechanisms in pain: CBF lesions vs systemic scopolamine. Read More »
Vitale EM, Holschbach MA, Lonstein JS (2016) Maternal aggression is impaired by prepartum serotonin-specific lesions of the midbrain dorsal raphe. Neuroscience 2016 Abstracts 338.01 / SS14. Society for Neuroscience, San Diego, CA. Summary: The postpartum period in laboratory rats and other animals is characterized by increased maternal responsiveness, decreased anxiety, and increased aggression. Pharmacologically manipulating