Targeting Trends Newsletter 17q1

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The locus coeruleus: a potential link between cerebrovascular and neuronal pathology in Alzheimer’s disease.

Contributed by S C Kelly, P T Nelson, S E Counts

From the President: Accelerating Your Research

The latest addition to the Ancheta family!

Fab-pHAST: The newest targeting tool

Recent Scientific References and Publications

  • Chen SK, Badea TC, Hattar S. (2011) Photoentrainment and Pupillary Light Reflex Are Mediated By Distinct Populations of Iprgcs. Nature 476(7358):92-95. PMID: 21765429 (Cat. #AB-N38)
  • Bourane S, Duan B, Koch SC, Dalet A, Britz O, Garcia-Campmany L, Kim E, Cheng L, Ghosh A, Ma Q, Goulding M. (2015) Gate Control of Mechanical Itch By a Subpopulation of Spinal Cord Interneurons. Science 350(6260):550-54. PMID: 26516282 (Cat. #IT-40)
  • Sorge RE, Mapplebeck JC, Rosen S, Beggs S, Taves S, Alexander JK, Martin LJ, Austin JS, Sotocinal SG, Chen D, Yang M, Shi XQ, Huang H, Pillon NJ, Bilan PJ, Tu Y, Klip A, Ji RR, Zhang J, Salter MW, Mogil JS. (2015) Different Immune Cells Mediate Mechanical Pain Hypersensitivity in Male and Female Mice. Nat Neurosci 18(8):1081-83. PMID: 26120961 (Cat. #IT-06)
  • Somasundaram P, Wyrick GR, Fernandez DC, Ghahari A, Pinhal CM, Simmonds Richardson M, Rupp AC, Cui L, Wu Z, Brown RL, Badea TC, Hattar S, Robinson PR. (2017) C-Terminal Phosphorylation Regulates the Kinetics of a Subset of Melanopsin-Mediated Behaviors in Mice. Proc Natl Acad Sci U S A 114(10):2741-46. PMID: 28223508 (Cat. #AB-N38)
  • Wang L, Conner JM, Nagahara AH, Tuszynski MH. (2016) Rehabilitation Drives Enhancement of Neuronal Structure in Functionally Relevant Neuronal Subsets. Proc Natl Acad Sci U S A 113(10):2750-55. PMID: 26903653 (Cat. #IT-01)
  • Ngo M, Han A, Lakatos A, Sahoo D, Hachey SJ, Weiskopf K, Beck AH, Weissman IL, Boiko AD. (2016) Antibody Therapy Targeting Cd47 and Cd271 Effectively Suppresses Melanoma Metastasis in Patient-Derived Xenografts. Cell Rep 16(6):1701-16. PMID: 27477289 (Cat. #IT-15)
  • Hay CM, Sult E, Huang Q, Mulgrew K, Fuhrmann SR, McGlinchey KA, Hammond SA, Rothstein R, Rios-Doria J, Poon E, Holoweckyj N, Durham NM, Leow CC, Diedrich G, Damschroder M, Herbst R, Hollingsworth RE, Sachsenmeier KF. (2016) Targeting Cd73 in the Tumor Microenvironment With Medi9447. Oncoimmunology 5(8):e1208875. PMID: 27622077 (Cat. #IT-51)
  • Lecrux C, Sandoe CH, Neupane S, Kropf P, Toussay X, Tong XK, Lacalle-Aurioles M, Shmuel A, Hamel E. (2017) Impact of Altered Cholinergic Tones on the Neurovascular Coupling Response to Whisker Stimulation. J Neurosci 37(6):1518-31. PMID: 28069927 (Cat. #IT-01)
  • Sakurai T, Kamiyoshi A, Kawate H, Mori C, Watanabe S, Tanaka M, Uetake R, Sato M, Shindo T. (2016) A Non-Inheritable Maternal Cas9-Based Multiple-Gene Editing System in Mice. Sci Rep 6:20011. PMID: 26817415 (Cat. #IT-10)
  • Silva TM, Takakura AC, Moreira TS. (2016) Acute Hypoxia Activates Hypothalamic Paraventricular Nucleus-Projecting Catecholaminergic Neurons in the C1 Region. Exp Neurol 285(Pt A):1-11. PMID: 27569537 (Cat. #IT-03)
  • Xia W, Liu Y. (2016) Targeted Ablation of Cardiac Sympathetic Neurons: A Promising Approach to Prevent Sudden Cardiac Death. Int J Cardiol 202:425-26. PMID: 26433164 (Cat. #IT-14)
  • Turnbull MT, Coulson EJ. (2017) Cholinergic Basal Forebrain Lesion Decreases Neurotrophin Signaling Without Affecting Tau Hyperphosphorylation in Genetically Susceptible Mice. J Alzheimers Dis 55(3):1141-54. PMID: 27767994 (Cat. #IT-16, IT-35)
  • Yuan X, Yang M, Chen X, Zhang X, Sukhadia S, Musolino N, Bao H, Chen T, Xu C, Wang Q, Santoro S, Ricklin D, Hu J, Lin R, Yang W, Li Z, Qin W, Zhao A. (2016) Characterization of the First Fully Human Anti-Tem1 Scfv in Models of Solid Tumor Imaging and Immunotoxin-Based Therapy. Cancer Immunol Immunother PMID: 27933426 (Cat. #IT-27)
  • Benn A, Robinson ES. (2017) Differential Roles for Cortical Versus Sub-Cortical Noradrenaline and Modulation of Impulsivity in the Rat. Psychopharmacology (Berl) 234(2):255-66. PMID: 27744551 (Cat. #IT-03)
  • Cai Y, Chew C, Muñoz F, Sengelaub DR. (2016) Neuroprotective Effects of Testosterone Metabolites and Dependency on Receptor Action on the Morphology of Somatic Motoneurons Following the Death of Neighboring Motoneurons. Dev Neurobiol PMID: 27569375 (Cat. #IT-14)
  • Maass JC, Gu R, Cai T, Wan YW, Cantellano SC, Asprer JS, Zhang H, Jen HI, Edlund RK, Liu Z, Groves AK. (2016) Transcriptomic Analysis of Mouse Cochlear Supporting Cell Maturation Reveals Large-Scale Changes in Notch Responsiveness Prior to the Onset of Hearing. PLoS One 11(12):e0167286. PMID: 27918591 (Cat. #AB-N01AP)
  • Iizuka K, Yokomizo T, Watanabe N, Tanaka Y, Osato M, Takaku T, Komatsu N. (2016) Lack of Phenotypical and Morphological Evidences of Endothelial to Hematopoietic Transition in the Murine Embryonic Head During Hematopoietic Stem Cell Emergence. PLoS One 11(5):e0156427. PMID: 27227884 (Cat. #FL-N01AP)
  • Wehner AB, Milen AM, Albin RL, Pierchala BA. (2016) The P75 Neurotrophin Receptor Augments Survival Signaling in the Striatum of Pre-Symptomatic Q175(wt/hd) Mice. Neuroscience 324:297-306. PMID: 26947127 (Cat. #AB-N01AP)
  • Amano M, Amiya N, Yokoyama T, Onikubo K, Yamamoto N, Takahashi A. (2016) Immunohistochemical Detection of Corticotropin-Releasing Hormone (Crh) in the Brain and Pituitary of the Hagfish, Eptatretus Burgeri. Gen Comp Endocrinol 236:174-80. PMID: 27444128 (Cat. #AB-02)
  • Tanigawa M, Suzuki C, Niwano K, Kanekatsu R, Tanaka H, Horiike K, Hamase K, Nagata Y. (2016) Participation of D-Serine in the Development and Reproduction of the Silkworm Bombyx Mori. J Insect Physiol 87:20-29. PMID: 26828952 (Cat. #AB-T049)
  • Jiao J, Xiong W, Wang L, Yang J, Qiu P, Hirai H, Shao L, Milewicz D, Chen YE, Yang B. (2016) Differentiation Defect in Neural Crest-Derived Smooth Muscle Cells in Patients With Aortopathy Associated With Bicuspid Aortic Valves. EBioMedicine 10:282-90. PMID: 27394642 (Cat. #AB-N07)

Talking about Targeting: Neurotransmitter Antibodies

Kermit’s Kollection

Where to See Us:

  • German Neuroscience Society, Göttingen, GERMANY  | March 22-25 | Booth #63
  • Amer Assoc Cancer Research,  Washington, DC USA | April 1-5 | Booth #2554
  • Experimental Biology, Chicago, IL USA | April 22-26 | Booth #462
  • Amer Assoc Immunologists, Washington, DC USA | May 12-16 | Booth #335

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