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Neurite outgrowth in cultured mouse pelvic ganglia – Effects of neurotrophins and bladder tissue

Ekman M, Zhu B, Swärd K, Uvelius B (2017) Neurite outgrowth in cultured mouse pelvic ganglia РEffects of neurotrophins and bladder tissue. Auton Neurosci 205:41-49. doi: 10.1016/j.autneu.2017.03.004 PMID: 28347639

Objective: To characterize the effects of the neurotrophins nerve growth factor (NGF), brain derived neurotrophic factor (BDNF) and neurotrophin 3 (NT-3) on the sprouting rate of sympathetic and parasympathetic neurites from the female mouse ganglion.

Summary: All three factors (BDNF, NT-3 and NGF) stimulated neurite outgrowth of both sympathetic and parasympathetic neurites although BDNF and NT-3 had a higher stimulatory effect on parasympathetic ganglion cells. Active forms of BDNF and NT-3 were detected in urinary bladder tissue, whereas tissue from the diaphragm expressed NGF.

Usage: in vitro culture (2 ul/ml)

Related Products: NGFR (mu p75) Rabbit Polyclonal, affinity-purified (Cat. #AB-N01AP)

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