Author name: Kristen Hartman

3D visualization of individual regenerating retinal ganglion cell axons reveals surprisingly complex growth paths

Bray ER, Noga M, Thakor K, Wang Y, Lemmon VP, Park KK, Tsoulfas P (2017) 3D visualization of individual regenerating retinal ganglion cell axons reveals surprisingly complex growth paths. eNeuro 4:ENEURO.0093-0017.2017. doi: 10.1523/ENEURO.0093-17.2017 PMID: 28856242 Summary: “Our study demonstrates extensive and circuitous RGC axon elongation both in pre- and post-lesion regions, highlighting the need to […]

3D visualization of individual regenerating retinal ganglion cell axons reveals surprisingly complex growth paths Read More »

Phrenic long-term facilitation following intrapleural CTB-SAP-induced respiratory motor neuron death.

Nichols NL, Craig TA, Tanner MA (2018) Phrenic long-term facilitation following intrapleural CTB-SAP-induced respiratory motor neuron death. Respir Physiol Neurobiol 256:43-49. doi: 10.1016/j.resp.2017.08.003 Objective: To study the impact of respiratory motor neuron death. Summary: Intrapleural CTB-SAP mimics aspects of ALS. Seven days of CTB-SAP enhances respiratory plasticity. Usage: Bilateral intrapleural injections of: 1) CTB-SAP (25 μg),

Phrenic long-term facilitation following intrapleural CTB-SAP-induced respiratory motor neuron death. Read More »

Blocking Microglial Channels: Mac-1-SAP as a Targeting Tool

Targeting Topics /

Blocking microglial pannexin-1 channels alleviates morphine withdrawal in rodents.  Burma, N.E., R.P. Bonin, H. Leduc-Pessah, et al.  Nat Med, 2017. 23(3): p. 355-360. PMID: 28134928 The authors investigated the mechanisms underlying opiate withdrawal in rat.  Depletion of spinal lumbar microglia by intrathecal injections of Mac-1–SAP (Cat. #IT-33; 20 mcg) decreased withdrawal behaviors and attenuated the severity of

Blocking Microglial Channels: Mac-1-SAP as a Targeting Tool Read More »

MOR-expressing neurons in Pain, Addiction and Mast Cell Function

Targeting Topics /

The rostromedial tegmental nucleus and alcohol addiction. Ye J-H, Fu R, He W. (2017). Impact Journals. 2017;8(12):18624-18625. The authors discuss their work (1) with Dermorphin-SAP (Cat. #IT-12) and their demonstration that damage of RMTg MOR-expressing GABAergic neurons by Dermorphin-SAP increased the intake and preference for alcohol, boosted the expression and slowed down the extinction of alcohol

MOR-expressing neurons in Pain, Addiction and Mast Cell Function Read More »

192-IgG-SAP and the Sleep Regulatory System

Targeting Topics /

Acute Effects of Alcohol on Sleep Are Mediated by Components of Homeostatic Sleep Regulatory System: An Editorial Highlight for ‘Lesions of the Basal Forebrain Cholinergic Neurons Attenuates Sleepiness and Adenosine after Alcohol Consumption.’ Alam, MN, & McGinty, D. (2017). J Neurochem 2017/07/25. In the study, titled ‘Lesions of the basal forebrain cholinergic neurons attenuates sleepiness and

192-IgG-SAP and the Sleep Regulatory System Read More »

CCK-SAP: a novel selective vagal deafferentation technique

Targeting Topics /

Validation and Characterization of a Novel Method for Selective Vagal Deafferentation of the Gut. Diepenbroek C, Quinn D, Stephens R, Zollinger B, Anderson S, Pan A, de Lartigue G. Am J Physiol Gastrointest Liver Physiol 2017. PMID: 28705805 The authors Injected CCK-SAP (Cat. #IT-31) into the nodose ganglia (NG) of rats to specifically ablate GI‐VAN

CCK-SAP: a novel selective vagal deafferentation technique Read More »

Acute effects of alcohol on sleep are mediated by components of homeostatic sleep regulatory system: An Editorial Highlight for ‘Lesions of the basal forebrain cholinergic neurons attenuates sleepiness and adenosine after alcohol consumption’ on page 710.

Alam M, McGinty D (2017) Acute effects of alcohol on sleep are mediated by components of homeostatic sleep regulatory system: An Editorial Highlight for ‘Lesions of the basal forebrain cholinergic neurons attenuates sleepiness and adenosine after alcohol consumption’ on page 710. J Neurochem 142(5):620-623.. doi: 10.1111/jnc.14100 Summary: In the study published in 2017, Sharma and

Acute effects of alcohol on sleep are mediated by components of homeostatic sleep regulatory system: An Editorial Highlight for ‘Lesions of the basal forebrain cholinergic neurons attenuates sleepiness and adenosine after alcohol consumption’ on page 710. Read More »

Lesion of the basal forebrain cholinergic neurons attenuates sleepiness and adenosine after alcohol consumption.

Sharma R, Sahota P, Thakkar M (2017) Lesion of the basal forebrain cholinergic neurons attenuates sleepiness and adenosine after alcohol consumption. J Neurochem 142:710-720.. doi: 10.1111/jnc.14054 Summary: This project examined the sleep-promoting effect of alcohol and which neurons in the brain are involved in the process. 192-IgG-SAP (Cat. #IT-01; 0.3 µg/500 nL/side) was administered through

Lesion of the basal forebrain cholinergic neurons attenuates sleepiness and adenosine after alcohol consumption. Read More »

Leveraging Siglec-8 endocytic mechanisms to kill human eosinophils and malignant mast cells.

O’Sullivan J, Carroll D, Cao Y, Salicru A, Bochner B (2018) Leveraging Siglec-8 endocytic mechanisms to kill human eosinophils and malignant mast cells. J Allergy Clin Immunol 141:1774-1785.e1777. doi: 10.1016/j.jaci.2017.06.028 Summary: Therapeutic payloads can be targeted selectively to eosinophils and malignant mast cells by exploiting this Siglec-8 endocytic pathway. Usage: Eosinophil cell death was assessed

Leveraging Siglec-8 endocytic mechanisms to kill human eosinophils and malignant mast cells. Read More »

Search
Shopping Cart
Scroll to Top